肺癌患者血清血管内皮细胞生长因子水平检测的临床意义  

Clinical Significance of serum vascular endothelial growth factor in lung Carcinoma

作　　者：林家进 曾雅静 马泽粦 

机构地区：[1]广东省阳江市江城区平岗医院外科,广东阳江529500 [2]阳江市江城区平岗医院内科,广东阳江529500 [3]东莞市慢性病防治院皮肤科,广东东莞523000

出　　处：《右江医学》2005年第2期116-117,共2页Chinese Youjiang Medical Journal

摘　　要：目的　检测肺癌患者的血清血管内皮细胞生长因子(VEGF),探讨血清 VEGF与肺癌患者的关系及临床意义。方法　用酶联免疫吸附法(ELISA)检测80例肺癌患者和30例健康正常人的血清VEGF含量,并进行对照分析。结果　肺癌患者的血清VEGF为160±15.3 pg/ml,明显高于健康正常人的40±20.6 pg/ml(t=33.192,P<0.01)。血清 VEGF浓度与患者的年龄、性别无关(P>0.05)。已手术切除、体内无明确病灶的手术和术后随访患者的血清VEGF浓度显著低于体内有明确病灶的初治和复治患者(P<0.01)。结论　监测肺癌患者的血清VEGF对判断肿瘤负荷、疗效、复发转移和预后都可能有重要参考价值。Objective To determine the level of serum vascular endothelial growth factor(VEGF) in patients with lung carcinoma and evaluate their clinic significance.Methods Serum VEGF were measured by sandwich enzyme linked immunoadsorbent assay(ELISA) in 80 patients with lung carcinoma and 30 healthy individuals, respectively. Results were compared.Results Serum VEGF levels(160±15.3pg/ml) in lung carcinoma was significantly higher than those in the normal controls(40±20.6pg/ml) (P<0.01). No correlation was found between gender and age. Conclusion Serum VEGF level has very important clinical significance in estimating tumor burden, therapeutic effectiveness,relapsing and metastasis of tumor,and prognosis in patients with lung carcinorma.

关 键 词：肺癌患者 临床意义 血管内皮细胞生长因子(VEGF) 水平检测 血清VEGF 酶联免疫吸附法 对照分析 手术切除 复治患者 术后随访 肿瘤负荷 参考价值 复发转移 正常人 健康 浓度 病灶 体内 

分 类 号：R734.2[医药卫生—肿瘤] R392.4[医药卫生—临床医学]