测定F-PSA/T-PSA对鉴别前列腺癌与前列腺增生的意义  被引量:5

Evaluation of measuring F-PSA/T-PSA to distinguish BPH from PCa

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作  者:官琳妹[1] 李士军[2] 

机构地区:[1]大连友谊医院检验科,辽宁大连116001 [2]大连医科大学第一临床学院检验科,辽宁大连116001

出  处:《大连医科大学学报》2005年第1期54-56,共3页Journal of Dalian Medical University

摘  要:[目的 ]通过测定血清中T -PSA与F -PSA的比值 ,探讨F -PSA/T -PSA在前列腺癌(PCa)与前列腺增生 (BPH)鉴别诊断中的价值。 [方法 ]采用罗氏电化学发光仪RocheElecsys10 10测定BPH和PCa患者血清中的T -PSA、F -PSA ,并计算F -PSA/T -PSA值。 [结果 ]T -PSA在 4 .0~ 5 0 .0 μg/L时 ,BPH和PCa患者有重叠区 ,而且在此区域内 ,两组患者的T -PSA差异无显著意义 (P >0 .0 5 ) ,而F -PSA/T -PSA值的差异有显著意义 (P <0 .0 5 )。 [结论 ]F -PSA/T -PSA值作为T -PSA的辅助指标 ,对T -PSA在 4 .0~ 5 0 .0 μg/L范围的PCa和BPH患者具有较大的鉴别诊断意义。Objective To explore the significance of F-PSA/T-PSA ratio in differential diagnosis between benign prostate hyperplasia (BPH) and prostate cancer (PCa) , through the detection of the level of serum total prostate specific antigen (T-PSA) and free PSA (F-PSA). [Methods] Two groups males with BPH and PCa were included in this study , F-PSA and T-PSA were measured with the Roche Elecsys 1010. The F-PSA/T-PSA was calculated based on the results.[Results] When T-PSA was between 4.0 and 50.0 μg/L, there was the range of overlapping of T-PSA in BPH and PCa patients, T-PSA couldn't be a differential maker for the two conditions (P>0.05) where as F-PSA/T-PSA ratio could (P<0.05).[Conclusion] F-PSA/T-PSA ratio being an adjuvant marker of T-PSA of importance on the differential diagnosis in patients when T-PSA is between 4.0~50.0 μg/L.

关 键 词:前列腺特异性抗原 前列腺癌 前列腺增生 

分 类 号:R737.25[医药卫生—肿瘤] R697.3[医药卫生—临床医学]

 

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