One-pot Synthesis of Isoxazolines Using Soluble Polymer-supported Acrylates  

作　　者：LanTAO PengFeiZHANG YiXinGU 

机构地区：[1]DepartmentofChemistry,HangzhouNormalCollege,Hangzhou310036

出　　处：《Chinese Chemical Letters》2005年第4期440-442,共3页中国化学快报（英文版）

摘　　要：An efficient and rapid parallel liquid-phase synthesis of isoxazolines has been reported. The one-pot three-component reaction of polyethylene glycol-supported acrylates, aldehydes and hydroxylamine hydrochloride in the presence of chloramine-T in methanol gave the corresponding PEG-supported isoxazolines, which can be cleaved from the support under mild condition to afford isoxazolines in good yields (>80%) and high purities (>86%).An efficient and rapid parallel liquid-phase synthesis of isoxazolines has been reported. The one-pot three-component reaction of polyethylene glycol-supported acrylates, aldehydes and hydroxylamine hydrochloride in the presence of chloramine-T in methanol gave the corresponding PEG-supported isoxazolines, which can be cleaved from the support under mild condition to afford isoxazolines in good yields (>80%) and high purities (>86%).

关 键 词：ISOXAZOLINES 1 3-dipolar cycloaddition soluble polymer liquid-phase synthesis polythylene glycol. 

分 类 号：O632.52[理学—高分子化学]