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This work was supported by the National Natural Science Foundation of China(21871174,22171178,21971159);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-09-E00008).The authors thank Prof.Chang-Hua Ding and Dr Mingchun Gao for their helpful discussions.Also,many thanks to Ms Jianjian Zha and Mr Shaohang Lu for performing the experiments for the revision.
α-Keto acids were unprecedentedly employed as novel precursors of nitrile oxides on treatment with copper nitrate,which reacted with maleimides via[3+2]dipolar cycloaddition leading to pharmacologically interesting f...
Supports from the National Natural Science Foundation of China (Nos. 21272257, 21274041 and 21474028)
NTrifluoromethyl and cyclopropyl substituted 2-isoxazolines were synthesized via a DBU-promoted domino reaction of β-trifluoromethyl-/β-cyclopropyl-substituted enones with hydroxylamine. The domino reaction consists...
Because of their convenience, oral dosage forms are an emerging trend in companion animal formulations. Ectoparasiticides represent a significant proportion of the treatments administered to pets, and recently oral fo...
Project 20572040 supported by National Natural Science Foundation of China.
3,5-Disubstituted 2-isoxazolines were oxidized to corresponding isoxazoles by nitric oxide in dichloromethane. The reaction more likely occurred via a one-electron transfer process.
The crystal structure of the title compound, diethyl 5-acetoxy-3-(4-chlorophenyl)-4,5- dihydroisoxazol-5-yl-5-phosphonate (C15H19CINO6P, Mr = 375.73), has been synthesized by the treatment of nitrile oxides and l-...
An efficient and rapid parallel liquid-phase synthesis of isoxazolines has been reported. The one-pot three-component reaction of polyethylene glycol-supported acrylates, aldehydes and hydroxylamine hydrochloride in...
A mild, regioselective 1, 3-dipolar cycloaddition protocol for the preparation of phenylselenomethyl isoxazolines through substituted allyl phenyl selenides and nitrile oxides was reported.
ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 9972 0 37)
An efficient liquid-phase synthesis of isoxazolines through a 1,3-dipolar cycloaddition is described. Soluble polymer-supported acrylate reacted with nitrile oxides generated in-situ, followed by cleavage from the sup...
NNSFC (20074017,29844001) and Visiting Scholar Foundation of Key Lab. In University
The solid-phase synthesis of isoxazolines on 2-polystyrylsulfonamidoethanol resin is reported. 2-Polystyrylsulfonamidoethanol resin 1 was reacted with acryloyl chloride to afford 2-polystyrylsulfonylamidoethyl acrylat...