γ－射线照射小鼠后F_1代中的染色体异常和显性致死突变研究  

Chromosome Abnormality and Dominant Lethality among the F_1 Generation of Mice after γ-ray Irradiation

作　　者：姚素艳[1] 张朝阳[1] 代连连 高长文 魏履新 

机构地区：[1]卫生部工业卫生实验所

出　　处：《Acta Genetica Sinica》1994年第3期188-192,共5页

基　　金：国家核安全局资助

摘　　要：１文报道雌鼠及雌雄性小鼠分别受到０．１５－１．５６Ｇｔ＾６０ｃｏγ－射线照射后，在不同时间进行同笼，取其胚胎观察形态、大小等并制备每个胚胎的染体标本。分析胚胎细胞染色体数目异常、结构畸变及显性致死效应。结果表明，染色体数目异常发生率与剂量呈直线关系。单纯雌鼠受到１．０７Ｇｙ照射后观察到平衡易位携带者的再现率为０．９９％。雌雄鼠均受到１．０７及１．５６Ｇｙ照射后观察到平衡易位携带者的再现率为０．This paper reports on the relationship between chromosome abnormality or dominant lethality and dosage of 0.15-1.56 Gy 60 Co γ-ray irradiation in the F_1 generation of mice.The irradiated female mice were mated at 7-12 days after irradiation with unirradiated or irradiated at 22-28 days after irradiation. The fetuses aged 9.5-11 day;were recovered from the uterus and lethality and chromosome aberrations were investigated.Results suggested that the rate of fetus with chromosome abnormality increased with dose,and so did dominant lethality rate,and both could fit linear relationship.Increase of translocation carriers in the F_1 mice was observed at the dose level of over 1.0 Gy.

关 键 词：染色体畸变 显性效应 致死 Γ射线 

分 类 号：Q345.22[生物学—遗传学]