蛋白质序列间进化距离的估计  

Estimation of Evolutionary Distances Between Protein Sequences

作　　者：杨子恒[1] 

机构地区：[1]北京农业大学畜牧系

出　　处：《Acta Genetica Sinica》1994年第3期198-200,共3页

摘　　要：本文考察了目前采用的估计同源蛋白质序列间进化距离的方法的缺陷，并提出了几个新的计算公式，它们考虑了氨基酸位点间显然存在的替代速率的差异。另外，提出了一种考虑氨基酸间不同替代概率的最大似然估计方法。文中对这些公式进行了计算比较。Several estimates of the evolutionary distance between two homologous protein sequences were deduced,taking into account of the variation of replacement rate over amino acid sites.A maximum likelihood estimator was also presented with consideration of different probabilities of replacement among amino acids.Suggestions were made as to the application of these distance estimates to real sequence analysis.

关 键 词：蛋白 进化距离 序列分化 

分 类 号：Q349.53[生物学—遗传学]