富铬酵母对大鼠实验性高脂血症的防治作用  

THE PREVENTIVE AND CURATIVE EFFECT OF CHROMIUM ENRICHED YEAST ON THE EXPERIMENTAL RATS WITH HYPERLIPIDEMIA

作　　者：常红[1] 庞文贞[1] 万里 董亚利[1] 刘莉[1] 赵利民[1] 

机构地区：[1]天津医学院

出　　处：《营养学报》1994年第3期285-291,共7页Acta Nutrimenta Sinica

基　　金：国家自然科学基金

摘　　要：观察含０．０７７ｎｍｏｌ／ｇＣｒ（Ⅲ）的富铬酵母对大鼠实验性高脂血症的防治作用，通过血脂、血铬及扫描电镜下主动脉内皮细胞超微结构的变化，探讨富铬酵母的降脂作用。结果表明，在给高脂饲料的同时按１８μｇＣｒ·ｋｇｂｗ（－１）．ｄ（－１）加入富铬酵母８０无后，大鼠ＴＣ、ＴＧ、ＬＤＬ－Ｃ增加值和ＨＤＬ－Ｃ、ＨＤＬ＿２－Ｃ下降值显著低于单纯食高脂饲料者。用本酵母１０μｇＣｒ·ｋｇｂｗ（－１）·ｄ（－１）治疗４０天后观察到，高血脂大鼠ＴＣ、ＴＧ、ＬＤＬ－ｃ显著下降，ＨＤＬ－ｃ、ＨＤＬ＿２－Ｃ、血清Ｃｒ显著上升，且效果优于月见草油。本文同时观察到，无论是用富铬酵母还是用月见草油来治疗，食基础饲料者比食高脂饲料者各项血脂水平均更接近于正常。从主动脉内皮细胞扫描电镜观察到，用本酵母预防８０天后大鼠病变较单纯食高脂饲料组轻。改用基础饲料同时食入富铬酵母的大鼠治疗后病变程度有所减轻，病变范围有所缩小。his study was conducted to investigate the preventive and curative cffect of 0.w7nmol/g Cr enriched yeast to experimental hyperlipidemiain rats. Serum lipid5, scrum Cr and ultrastructural pathological change onthe aortic wall under the scanning electron microscope were observed. Theresults showed that: after feeding on fat enriched ration with Cr enrichedyeast 18μg Cr·kg bw￣(-1). d ￣(-1) for 80 days,the value of TC, TG, LDL-C increa-sed and the value of HDL-c, HDL2-C decreased in the group woth Cr sup-plementation were less than the control group. When Cr enriched yeast 10μgCr·kg bw(-1)·day(-1) were given to the hyperlipidemic rats for 40 days, serum TC,TG, LDL-C decreased signficantly, HDL-C, HDL_2-C and serum Cr in crea-sed obviously. The antihyperlipidemic effect of this yeast was better thanOenotheria binnis seed oil. The results of ultrastructural pathological cha-nge showed that: in the preventive test, the cellular swelling, atrophy, widening of intercellular space, worm-eaten-like holes and aggregation of lcukocytes on the vascular wall were lighter than the control group with enriched food. After alternation from fat enriched tation to basic ra-tion and taking Cr enriched yeast, the degree of pathological change in the aortic endothelium was relieved.

关 键 词：富铬酵母 血脂 高血脂病 

分 类 号：R151.1[医药卫生—营养与食品卫生学]