手性酒石酸二酰胺配体的合成及其锡络合物与苯甲醛的不对称加成  

Synthesis of Chiral Diamide Ligands of Tartaric acid and Asymmetric Addition of Their Tin Complexes with Benzaldehyde

作　　者：谭万会 张三奇[2] 张生勇[2] 冯锐[3] 

机构地区：[1]陕西省化学研究所,陕西西安710069 [2]第四军医大学化学教研室 [3]军事医学科学院,北京100850

出　　处：《有机化学》1994年第2期181-184,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金资助课题

摘　　要：高烯丙醇类化合物由于同时含有—OH和C=C两个官能团,所以在有机合成中是一类重要的中间体。η—烯丙基金属络合物与碳基的亲核加成反应是合成这类化合物的常用方法(eq.(+)-N, N'-diphenyl tartaric acid diamide 2, (+)-N, N'-dibenzyl tartaric acid diamide 3, (+)-dicyclohexyl tartaric acid diamide 4, and (+)-N, N'-di-n-octyl tartaric acid diamide 5 are synthesized via the amidate of diethyl tartarate and corresponding amine, respectively. Chiral tin complexes 6 are also prepared by treatment of tin dichloride with 2 equiv. of doubly deprotonated tartaric acid diamide followed by addition of an allylic bromide. The reaction of 6 with benzaldehyde affords optically active homoallyic alcohols in 42-64% yield and in 24-62% e.e..

关 键 词：锡铬合物 苯甲醛 酒石酸二酰胺 

分 类 号：O614.432[理学—无机化学]