地诺孕素的~1HNMR及^(13)CNMR研究  

~1HNMR and ^(13)CNMR Study on Dienogest

作　　者：丁丽[1] 卢彦昌[2] 陈立功[1] 凌仰之[2] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]天津药业研究院有限公司,天津300161

出　　处：《中国医药工业杂志》2005年第4期220-222,共3页Chinese Journal of Pharmaceuticals

摘　　要：研究并全面归属了地诺孕素的HNMR与13CNMR图谱。以CDCl3为溶剂,TMS为内标,进行NMR实验,利1用1H-1H COSY,HMQC,HMBC等2D-NMR技术进行解析。对?4,9-二烯-3-酮类新甾体药物的NMR谱解析有一定帮助。HNMR and CNMRspectrums of dienogest were investigated and completely assigned by combina- 13 tion of 2D-NMR techniques such as H-1H COSY, HMQC and HMBC. CDCl3 and TMS were used as the solvent and the 1 internal standard, respectively. This would be helpful for assigning NMR of various new steroidal drugs which have ?4,9- diene-3-oneskeleton.

关 键 词：地诺孕素 核磁共振波谱 氢谱 碳谱 结构鉴定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.63[化学工程—制药化工]