全身性热化疗治疗晚期胰腺癌的临床观察  

Treatment of advanced pancreatic carcinoma by whole body hyperthermic chemotherapy

作　　者：张蓓[1] 刘志苏[1] 罗先文[2] 黄汉涛[2] 袁建国[2] 

机构地区：[1]武汉大学中南医院普外科,430071 [2]武警湖北省总队医院普外科

出　　处：《腹部外科》2005年第2期92-93,共2页Journal of Abdominal Surgery

摘　　要：目的　探讨全身性热化疗治疗晚期胰腺癌的效果,以及化疗药物在此过程中代谢的变化。方法　将42例晚期胰腺癌病人分成2组,分别接受全身性热化疗和单纯化疗后,比较二者的疗效、不良反应及5 FU的药代动力学指标。结果　实验组具有较好的疗效,不良反应的发生率随之提高,其体内化疗药物的相对浓度升高。结论　全身性热化疗是一种有效的治疗晚期胰腺癌的方法,其机理与化疗药物在体内有效浓度的增加有密切的关系。Objective To investigate the effects of whole body hyperthermic chemotherapy for advanced pancreatic adenocarcinoma and the metabolic change of 5-FU during this experiment.Methods Forty-two untreated patients were divided into two groups:the experimental group received whole body hyperthermic chemotherapy and the control group received chemotherapy only.The therapeutic effectiveness,side effects and pharmacokinetics of 5-FU were compared between the two groups.Results The objective response and CBR in experimental group and control group was 42.3% vs 14.3% ,and 76.2% vs 33.3% respectively.There was a significant increase in systemic(5-FU)exposure and toxicity in the experimental group.Conclusion It is certain for the combined application of hyperthermia and 5-FU to treat pancreatic adenocarcinoma.The enhanced 5-FU systemic exposure found in the presence of GEM may explain the higher level of toxicity and antitumour activity in this trial.

关 键 词：晚期胰腺癌 化疗治疗 全身性 临床观察 化疗药物 不良反应 胰腺癌病人 动力学指标 5-FU 有效浓度 热化疗 化疗后 实验组 发生率 疗效 体内 

分 类 号：R735.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]