永生宜康醒酒和减轻酒精致动物肝损伤药效学试验  

Pharmacodynamics Experiments of Yongsheng Yikang to Sober up Drinkers and to Alleviate Hepatic Injury Caused by Alcoholism

作　　者：袁秉祥[1] 孙晓东[1] 罗笑宇[1] 于晓江[1] 

机构地区：[1]西安交通大学医学院临床药理研究所,陕西西安710061

出　　处：《酿酒科技》2005年第4期90-92,共3页Liquor-Making Science & Technology

摘　　要：永生宜康(酒用添加剂)是以蜂蜜、葡萄糖、氨基酸、食用醋等为原料,经发酵后浓缩、提纯出的浅橙色液体,其作用可减小酒精对人体的刺激,起到醒酒、保肝、减毒作用。本实验采用酒精致动物肝损伤模型,在酒中加永生宜康后给小鼠连续灌胃2个月,观察永生宜康的药效学作用。实验结果表明,对小鼠的体重增长有明显的保护作用;可缩短醉酒小鼠的醒酒时间;血清生化指标测试的数据和肝脏切片与对照组比较的病理学检查结果证明,可降低血清中谷草、谷丙转氨酶、减轻酒精对肝脏的损伤程度。说明永生宜康能减轻酒精中毒,对肝脏起到一定的保护作用。永生宜康急性毒性实验,LD50大于60mL/kg体重,是人每天最大用量的900倍,未见异常,属无毒级。Honey, glucose, amino acids and edible vinegar etc. were used as raw materials to produce Yongsheng Yikang (additive for liquor). After the fermentation and the condensation of the raw materials, orange liquid Yongsheng Yikang was obtained by purification and distillation, which had the functions of sober up, liver protection and poisoning-alleviating. Alcoholism-caused animal hepatic injury models were used in this experiment. Yongsheng Yikang was added into liquor, then two-month consecutive liquor stomach-filling of rats were done, then pharmacodynamics of Yongsheng Yikang were studied. The experimental results indicated that Yongsheng Yikang had significant protection effects on weight increase of rats and it could shorten rats' sober-up time. Serum biochemical index measurement data and pathologic results of the contrast of liver slices proved that Yongsheng Yikang could reduce the contents of cereal straw and glutamatepyruvate transaminase (GPT) and alleviate hepatic injury caused by alcoholism. Anyhow, Yongsheng Yikang could alleviate alcoholism and protect liver. Its acute toxicity experiments suggested LD50 higher than 600 mL/kg, 900 times of daily maximum usage of human being, and it belonged to nontoxic substances. (Tran. by YUE Yang)

关 键 词：永生宜康 醒酒 解毒 保肝降酶 

分 类 号：R285[医药卫生—中药学]