农药鱼藤酮的遗传毒性鉴定  

Genotoxicity identification on the pesticide of rotenone

作　　者：杨黠[1] 董兆君[1] 范舒[1] 蔡颖[1] 

机构地区：[1]第三军医大学军事毒理学教研室,重庆400038

出　　处：《疾病控制杂志》2005年第2期125-127,共3页Chinese Journal of Disease Control and Prevention

基　　金：国家自然科学基金资助项目 (30 4 0 0 347)

摘　　要：目的　检测农药鱼藤酮的遗传毒性。方法　用Ames实验检测回复突变作用,以CHL细胞实验和微核实验检测染色体畸变效应。结果　阳性对照剂能诱导显著的突变效应,鱼藤酮在所选用剂量范围内不能诱导显著的突变效应。Objective To investigate the genotoxic activity of the pesticide of rotenone. Methods Backward mutation was detected by the Ames test. The chromosome aberrations (CA) was detected by the CHL cells test and the micronuclei test (MN). Results The control substances can induce the mutation obviously. The pesticide rotenone, however, could not increase the frequency of backward mutation and CA at the chosen concentrations. Conclusions The pesticide of rotenone may not show obvious mutagenesis.

关 键 词：鱼藤酮 农药 突变 遗传毒性 鉴定 

分 类 号：R992[医药卫生—毒理学]