α晶状体蛋白的研究进展  

Progression of alpha crystalline protein

作　　者：刘康[1] 王一[1] 

机构地区：[1]第三军医大学西南医院眼科,重庆市400038

出　　处：《眼科新进展》2005年第2期171-173,共3页Recent Advances in Ophthalmology

基　　金：全军医药卫生科研基金资助(编号:01Z039)~~

摘　　要：α晶状体蛋白包括αA和αB晶状体蛋白,属于小分子热休克蛋白家族成员。α晶状体蛋白在晶状体中为主要的屈光介质,同时具有分子伴娘的功能。αA晶状体蛋白主要存在于晶状体,在脾和胸腺有微量表达。αB晶状体蛋白在许多器官、组织、细胞均有结构性表达,在抵御内、外环境应激发挥重要作用。本文对α晶状体蛋白的分子量及结构,在晶状体内、外中的作用,与神经系统疾病的关系及α晶状体蛋白基因敲除研究等方面作一综述。Alpha-crystallin includes α A and α B-crystallins,being a member of the small heat-shock protein family.Alpha-crystallin is one of the major protein components that produce the necessary refractive index in the lens,having some of the properties of molecular chaperones.Alpha A crystalline is found mainly in the lens with trace amounts in other tissues.Alpha B is constitutively expressed in many organs,tissues,and cells.It holds some functions of resisting environment stress in vivo and in vitro.This review deals with some of the function and structure of alpha crystalline.

关 键 词：α晶状体蛋白 小分子热休克蛋白 基因敲除 

分 类 号：R776[医药卫生—眼科]