红花黄素注射液对大鼠脑缺血再灌注损伤的影响  

Protective effects of safflor yellow on rats during cerebralischemia/reperfusion

作　　者：陈铎葆[1] 贺明盟[2] 

机构地区：[1]安徽理工大学医学院,淮南232001 [2]淮南矿工三院检验科

出　　处：《陕西医学杂志》2005年第4期393-395,共3页Shaanxi Medical Journal

基　　金：安徽理工大学硕博基金项目 (2 0 0 2 DG2 2 8);安徽省教育厅自然科学研究项目(2 0 0 4kj1 3 5 )

摘　　要：目的:观测红花黄素注射液对大鼠脑缺血再灌注损伤的保护作用。方法:采用结扎大鼠双侧颈总动脉30 min后,恢复再灌注60 min,建立脑缺血再灌注模型,观测红花黄素注射液对脑组织含水量、脑组织匀浆中Na+及Ca2 +浓度、Glu、Asp、GABA、Gly及MDA的动态变化。结果:红花黄素注射液可明显降低缺血再灌注大鼠脑组织含水量、脑组织内Ca2 +、Glu、Asp、Gly、GABA及脂质过氧化产物丙二醛( MDA)含量。结论:红花黄素有抑制大鼠脑缺血再灌注损伤作用,其机制可能与其抑制脑组织内Ca2 +及兴奋性氨基酸含量。Objective: To study protective effects of safflor yellow on rats during cerebral ischemia/reperfusion. Methods: Cerebral ischemia/ reperfusion injury was produced by bilateral ligation of the common carotid arteries for 30 min and reperfusion for 60 min. Contents of water,MDA,Glu,Asp,Gly,GABA and Ca 2+ and Na + in brain tissue were determined . Resluts: During Cerebral ischemia/reperfusion , safflor yellow improved contents of Glu,Asp,Gly,GABA and Ca 2+ and Na +,while decreasing the malondialdehyde content in the brain and brain water content. Safflor yellow had significantly scavenging effects on oxygen free radicals produced by cerebral ischemia/ reperfusion injury. Conclusions: The results indicate that safflor yellow can reduce the injury on cerebral ischemia/reperfusion in rats for OFR,these effects may be related to its scavenging effects on oxygen free radicals and inhibiting the release of free radicals.

关 键 词：脑缺血再灌注损伤 红花黄素 注射液 大鼠 脑组织内Ca^2+ 脑缺血再灌注模型 丙二醛(MDA) 抗脂质过氧化作用 脑组织含水量 CA^2+浓度 脂质过氧化产物 GABA 脑组织匀浆 氨基酸含量 颈总动脉 保护作用 Na^+ 动态变化 损伤作用 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R285.5[医药卫生—临床医学]