MT1-MMP的表达与上皮性卵巢癌生物学特性及预后关系的研究  

Study on expression of MT1-MMP in epithelial ovarian cancer and correlation with biological characteristics and prognosis

作　　者：陈沂[1] 吴绪峰[1] 陈惠祯[1] 

机构地区：[1]武汉大学中南医院妇瘤科,湖北武汉430071

出　　处：《现代肿瘤医学》2005年第2期167-169,共3页Journal of Modern Oncology

基　　金：湖北省教委资助项目(No. 2001A14006)

摘　　要：目的　研究膜型基质金属蛋白酶-1(membranetype-1matrixmetalloproteinase,MT1-MMP)蛋白在上皮性卵巢癌组织中的表达及意义。方法　应用免疫组化SP法检测56例上皮性卵巢癌、15例上皮性卵巢良性肿瘤及10例正常卵巢组织中MT1-MMP的表达和微血管密度(microvesseldensity,MVD)。结果　MT1-MMP在卵巢癌组织中的阳性表达率(67. 9% )显著高于卵巢良性肿瘤(4 /15)和正常卵巢组织(1 /10) (P<0. 01)。MT1-MMP的表达水平与临床分期、组织学分级、有无淋巴结转移和MVD密切相关。在单因素生存分析中,MT1-MMP的表达与患者预后不良有关。结论　MT1 -MMP在上皮性卵巢癌中的异常高表达可能在肿瘤的侵袭转移和血管生成中起重要作用,对判断预后有一定的指导意义。Objective To study the expression and significance o f MT1-MMP protein in epithelial ovarian cancer. Methods Im munohistochemical staining (SP method) was used to detect the expression of MT1- MMP protein and MVD in 56 epithelial ovarian cancer, 15 epithelial benign tumors of ovary, and 10 normal ovary tissues. Results The expre ssion of MT1-MMP protein in epithelial ovarian cancer (67.9%) was significantly higher than those in benign ovarian tumor (4/15) and normal ovary(1/10)( P<0.01). The expression level of MT1-MMP correlated with FIGO staging , differentiation, lymph node metastasis and MVD. Expression of MT1-MMP showed a significant influence on survival in univariate analysis. Conclusion Overexpression of MT1-MMP in epithelial ovarian cancer may play an important role during tumor angiogenesis, invasion and metastasis. Moreover, it may be of value in predicting the patients' prognosis .

关 键 词：卵巢肿瘤 膜型基质金属蛋白酶-1 侵袭转移 预后 

分 类 号：R737.31[医药卫生—肿瘤]