甲地孕酮联合PLF(双周疗法)方案治疗鼻咽癌的临床研究  

Clinical study of nasopharygeal carcinoma treated with megestrol acetate and PLF(biweek schedule)

作　　者：赵小琼[1] 邓卫警[1] 朱瑰红[1] 欧雪萍[1] 欧超英[1] 王文珣[1] 

机构地区：[1]广东省农垦中心医院肿瘤三区,广东湛江524002

出　　处：《现代肿瘤医学》2005年第2期237-238,共2页Journal of Modern Oncology

摘　　要：目的　评价甲地孕酮联合PLF(双周疗法)对鼻咽癌新辅助化疗近期疗效的提高作用与不良反应。方法　52例住院的鼻咽癌患者随机分为甲地孕酮+PLF化疗组(n=25)和单纯PLF化疗组(n=27),所有病人均接受2疗程的治疗。结果　治疗组有效率(CR+PR) 88. 0%,对照组有效率92. 6%,两者间无显著性差异(P>0. 05),治疗组的不良反应低于对照组,白细胞下降、消化道反应差异均有显著性(P<0. 05 ),而其它不良反应比较差异无显著性(P>0. 05)。结论　甲地孕酮配合化疗可以改善鼻咽癌患者的生存质量,减轻化疗所致的不良反应,值得临床推广应用。Objective To assess the anti-tumor efficacy and s af ety of neo-adjuvant chemotherapy of megestrol acetate and PLF(biweek schedule) in the treatmen of nasopharygeal carcinoma. Methods A ll 52 cases in-hospital nasopharygeal carcinoma patients were randomly divided i nto treated group 25 cases and control group 27 cases.Treated group megestrol a cetate plus PLF chemotherapy,control group single PLF chemotherapy. R esults The objective respone rate (CR+PR) was 88.0% in treatment gro up compared to 92.6% in control group (P>0.05). Nauaea, vomiting a nd leucopenia had significant differences between two regimens(P<0 .05). Conclusion Reasonable use of megestrol acetate can improve the life quality of nasopharygeal carcinoma partients in chemotherapy .

关 键 词：鼻咽癌 甲地孕酮 新辅助化疗 顺铂 大剂量醛氢叶酸 氟尿嘧啶 

分 类 号：R739.63[医药卫生—肿瘤]