康莱特联合顺铂治疗恶性胸腔积液疗效观察  

Effect of Kang LaiTe injection and PDD in treatment of malignant pleu ral effusion

作　　者：贾锋[1] 侯美英[1] 侯美红[1] 刘元建[1] 曹翠娟[1] 李亭山[1] 

机构地区：[1]山东省济宁医学院附属金乡人民医院,山东济宁272200

出　　处：《现代肿瘤医学》2005年第2期249-250,共2页Journal of Modern Oncology

摘　　要：　目的　观察康莱特联合顺铂(PDD)治疗胸腔积液的近期疗效和毒副作用。方法　48例恶性胸腔积液患者,先采用美国Arrow公司生产的一次性单腔中心静脉导管,进行胸腔穿刺置管和闭式引流胸水,再给予胸腔内注药,其中A组(n=25 )康莱特加顺铂,B组(n=23 )顺铂。康莱特每次注入100ml,顺铂每次注入50mg/m2,每周注射1次,连续注射2周,一个月后观察两组的疗效及不良反应。结果　康莱特加顺铂对恶性胸腔积液的有效率为80%,优于顺铂单用组。结论　胸腔闭式引流后注入康莱特加顺铂,治疗恶性胸腔积液,疗效肯定,是控制恶性胸腔积液的有效方法。Objective To evaluate the response and ad ve rse reactions of Kang LaiTe injection and PDD in treatment of malignant pleural effusion.Methods All 48 patients with malignant pleural e ffusion were applied with single lumen central venous cathetes made by Arrow Com pany.All patients were received the closed thoracic drainage and divided into tw o groups.The patients in group A(n=25) were treated by intracavity injection of Kang LaiTe and PDD,and those in group B(n=23)were treated by intracavity injecti on of PDD. Kang LaiTe injection at a dose of 100ml every time,was injected intra pleurally and that of PDD was 50mg/m2 every time.The above dosage was given on e time/week for 2 weeks.The therapeutic effect and adverse reactions were observ ed after one month.Results Overall objective response rat e(complete+partial remission) of 80%(20/25) in the group A was higher than that of 52.2% in the group B.Conclusion After draining complet ely the pleural fluid,the intracavity injection of Kang LaiTe and PDD is more ef fective for the treatment of malignan pleural effusion.

关 键 词：恶性胸腔积液 胸腔闭式引流 康莱特 顺铂 

分 类 号：R730.53[医药卫生—肿瘤]