RNA干扰与肿瘤的基因治疗  

RNA interference and tumor gene therapy

作　　者：薛祥云[1] 尤永平[2] 刘宁[2] 

机构地区：[1]江苏省淮安市第三人民医院神经外科 [2]南京医科大学附属医院神经外科,210029

出　　处：《中华神经医学杂志》2005年第3期317-319,共3页Chinese Journal of Neuromedicine

摘　　要：RNA干扰(RNAi)是指双链RNA(dsRNA)在细胞内特异性诱导同源互补的mRNA降解,从而阻断相应基因表达的现象。随着哺乳动物RNA干扰的研究不断取得进展,RNA干扰显示出作为一种新型肿瘤基因治疗方法的巨大优越性。初步的实验结果表明,用RNA干扰治疗癌症的设想有可能变成现实。RNA interference (RNAi) refers to homologous complementary mRNA degradation induced specifically by double-stranded RNA, which actually interdicts the expression of corresponding genes. The continual development of the study on mammiferous RNAi shows its tremendous advantage as a novel genetic therapeutic technique on tumor. Pilot studies have indicated that tentative plan of treating tumor by RNAi technology may be turned into reality.

关 键 词：RNA干扰 肿瘤 基因治疗方法 MRNA 哺乳动物 基因表达 治疗癌症 性诱导 细胞内 优越性 

分 类 号：R730.5[医药卫生—肿瘤]