肾透明细胞癌CT分期与PCNA和bcl-2表达的相关性探讨  

Correlation of CT Staging with PCNA and Bcl-2 Expression in Renal Clear Cell Carcinoma

作　　者：彭泽华[1] 白林[1] 熊焰[2] 蒲红[1] 李刚[1] 何远智[1] 陈加原[1] 付凯[1] 赵世煜[1] 

机构地区：[1]四川省人民医院放射科,成都610072 [2]四川省人民医院病理科,成都610072

出　　处：《放射学实践》2005年第4期342-344,共3页Radiologic Practice

摘　　要：目的:分析肾透明细胞癌的CT分期与增殖细胞核抗原(PCNA)和bcl 2表达的关系。方法:对51 例经手术病理证实的肾透明细胞癌,采用免疫组化LDP法检测肿瘤标本中PCNA和bcl 2的表达,并对肿瘤进行病理分级,分析其与术前CT分期的关系。结果:PCNA表达与CT分期及病理各分级间具有相关性(P<0.05),在CT分期中Ⅰ期与Ⅲ期、Ⅰ期与Ⅳ期、Ⅱ与Ⅲ期、Ⅱ与Ⅳ期、Ⅰ+Ⅱ与Ⅲ+Ⅳ期的PCNA表达差异有显著性意义(P<0.05),而bcl 2 表达与肿瘤病理分级及CT分期均无明显相关(P>0.05)。结论:PCNA的表达与肾透明细胞癌的CT分期、病理分级具有相关性,能较为客观、准确的反映肾透明细胞癌的恶性程度,对选择治疗方法有重要的参考价值。Objective:To discuss the correlation between CT staging and proliferating cell nuclear antigen (PCNA) and bcl-2 expression in renal clear cell carcinoma (RCCC).Methods:The expression of PCNA and bcl-2 was estimated with LDP immunohistochemical technique in 51 cases with pathologically proved RCCC.The relation between CT staging and the expression of PCNA and bcl-2 was retrospectively analyzed.Results:PCNA expression correlated with CT staging and pathological grading (P<0.05).PCNA expressin between Ⅰand Ⅲ,Ⅰand Ⅳ,Ⅱand Ⅲ,ⅡandⅣ,Ⅰ+Ⅱand Ⅲ+Ⅳ in CT staging (Ⅲ Ⅳ) had significant difference (P<0.05).Bcl-2 expression carried no relation with the CT staging and grade of the tumor.Conclusion:The expression of PCNA is related to the CT staging and pathological grade of the RCCC. It can accurately reflect the malignant degree of the RCCC,and has important reference value to select treating plans.

关 键 词：肾肿瘤 体层摄影术 X线计算机 增殖细胞核抗原 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]