6-马来酰亚胺基己酸的合成与表征  

Synthesis and Characterization of 6-Maleimido Caproic Acid

作　　者：刘东华[1] 王孝杰[2] 李效东[2] 徐满才[1] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]国防科技大学航天与材料工程学院,湖南长沙410073

出　　处：《合成化学》2005年第2期183-184,共2页Chinese Journal of Synthetic Chemistry

摘　　要：以氨基己酸和马来酸酐为原料,乙酸酐、乙酸钠作催化剂,在室温下反应5h,合成了一种新的可用于蛋白质、多肽药物修饰的“间隔臂”6-马来酰亚胺基己酸,产率90.34%,其结构经1HNMR,IR和LC-MS表征。Maleimido caproic acid, a new potential space arm in modification of protein and peptide drugs, was synthesized by the reaction of 6-aminocaproic acid and maleic anhydride at room temperature in 5.0 h by using acetic anhydride and sodium acetate as a catalyst, and the yield reached 90.34%. The structure was characterized by 1H NMR, IR and LC-MS.

关 键 词：间隔臂 药物修饰 蛋白质 己酸 马来酸酐 合成 

分 类 号：O623.6[理学—有机化学]