玻璃体内使用维拉帕米对兔眼视网膜电流图作用电量的研究  

Effect of verapamil through intravitreal injection on retina of rabbit

作　　者：刘驰[1] 于秀玲[1] 刘哲丽[1] 

机构地区：[1]中国医科大学附属第一医院眼科

出　　处：《中国医科大学学报》2005年第2期134-135,共2页Journal of China Medical University

摘　　要：目的: 探讨玻璃体内使用不同浓度的维拉帕米对兔眼视网膜电流图的影响。方法:采用纯系日本大耳白兔共9只,随机分成3组,每组6只眼,向玻璃体内注入不同浓度的维拉帕米溶液。术前、术后进行视网膜电流图检查及眼底检查。结果:各用药组暗适应视网膜电流图最大反应b波振幅的测定值与用药前比较,无显著性差异(P>0.05)。结论:玻璃体内注入1. 0mg维拉帕米对兔眼及其视网膜电流图无影响。维拉帕米可用于眼底增殖性疾病治疗的研究。Objective: To investigate the retinal toxicity of verepamil through intravitreal injevtion. Methods: Nine white rabbits were randomly divided into 3 groups, which received intravitreal injection of verapamil of different dosage. Ophthalmoscopy and electroretinography (ERG) were performed after drug injection. Results: There was no difference in b-wave anplitudes in the control and verapamil treated groups. Conclusion: Verapamil of 1.0 mg through intravitreal injection had no retinal toxic effect.This study may provide a baseline for further clinic investigation, and verapamil may be used to treat proliferative eye diseases.

关 键 词：增殖性玻璃体视网膜病变 维拉帕米 视网膜电流图 

分 类 号：R770.43[医药卫生—眼科]