胃癌组织中p27基因和增殖细胞核抗原的表达与关系  

P27 Gene and PCNA Expressions and Significance in Primary Gastric Carcinoma

作　　者：曾思务[1] 刘雨[1] 潘玉玲[1] 姚晋林[2] 王世民[2] 阎军[2] 赵秉化[2] 

机构地区：[1]日照市人民医院外科,山东日照276800 [2]山西医科大学第一附属医院普外科,山西太原030001

出　　处：《河南肿瘤学杂志》2005年第2期119-120,共2页Henan Journal of Oncology

摘　　要：目的　观察胃癌组织中p2 7基因的表达和增殖细胞核抗原(PCNA)染色强度指数间的关系及临床意义。方法　采用LSAB免疫组织化学法。结果　在68例原发性胃癌组织中,p2 7基因阳性表达率47 0 6% (3 2 /68) ,PCNA染色指数平均为5 9 18±3 2 8,p2 7基因阳性率和PCNA染色指数在组织学分级Ⅰ级中明显低于组织学分级Ⅲ级(P <0 0 1) ;在无淋巴结转移者中明显低于有淋巴结转移者(P <0 0 5 )。结论　胃癌组织中p2 7基因的表达和PCNA染色指数与胃癌的发生、发展密切相关,可以客观反映胃癌的组织分化状态,肿瘤进展及转移潜力。Objective To observe the relationship between the expression of p27 gene and the indices of PCNA in primary gastric carcinoma.Methods Immunohistochemistry of labelled streptavidin biotin method was used in this study.Results The positive rate of p27 gene and mean indices of PCNA in the group with histological gradeⅠbut without lymphaden metastasis were significantly lower than those in the group with histological grade Ⅲ and lymphaden metastasis (P<0.01,P<0.05).Conclusions The results further showed that the expression of p27 gene and indices of PCNA might be related to the genesis and development of gastric carcinoma. High-levels of p27 expression and indices of PCNA in gastric carcinoma may be associated with poor differentiation, rapid progression, and high risk of lymphaden metastasis.

关 键 词：原发性胃癌 P27基因 增殖细胞核抗原 

分 类 号：R735.2[医药卫生—肿瘤]