Relationship between the Expression of E-cadherin and Microvessel Density in Lung Cancer and Its Significance  

肺癌中E-钙粘蛋白的表达与微血管密度的关系及意义(英文)

作　　者：王新允[1] 杨菊红[1] 马莹[1] 程波[1] 郑宏伟[1] 郑海燕[1] 朱丛中[1] 刘婷[1] 李艳[1] 王爱香[1] 孙翠云[1] 

机构地区：[1]天津医科大学病理教研室,300070

出　　处：《The Chinese-German Journal of Clinical Oncology》2005年第2期99-101,共3页中德临床肿瘤学杂志（英文版）

基　　金：This study is a key project of Tianjin Scientific Committee (No. 033804211).

摘　　要：To study the relationship between the expression of E-cadherin andmicrovessel density (MVD) in lung cancer. Methods: The expression of E-cadherin and factor VIII wasdetected in 104 lung cancer tissues by an immunohistochemical method, and MVD was calculated by animage-analysis system. Results: The expression of E-cadherin was significantly related to thedifferentiation of lung cancers (P 【 0.05). A negative correlation was found between E-cadherinexpression and MVD in lung cancer tissues (P=0.047). Conclusion: Down-expression of E-cadherin andan increase of MVD may play an important role in the invasion and metastasis of lung cancer, and mayalso be used as a useful marker for tumor prognosis.

关 键 词：lung neoplasms E-CADHERIN microvessel density 

分 类 号：R734.2[医药卫生—肿瘤]