大叶蒟中抗抑郁酰胺类化合物  

Antidepressant amides from Piper laetispicum C. DC.

作　　者：潘胜利[1] 解静[2] 钱伏刚[2] 王峻[1] 邵衣慈[2] 

机构地区：[1]复旦大学药学院,上海200032 [2]上海医药工业研究院,上海200040

出　　处：《药学学报》2005年第4期355-357,共3页Acta Pharmaceutica Sinica

基　　金：上海市重中之重药学学科项目

摘　　要：目的　研究胡椒科植物大叶蒟(PiperlaetispicumC.DC. )的抗抑郁活性成分。方法　用动物实验进行活性跟踪,硅胶柱反复分离、纯化,应用MS,UV,IR,NMR鉴定化合物结构。结果　从 95%乙醇提取物的乙酸乙酯萃取部位分离得到 3个具有抗抑郁活性的酰胺类化合物,分别鉴定为N isobutyl ( 3, 4 methylendioxyphenyl) 2E, 4E, 9E undecatrienoamide(I), N isobutyl 9 phenyl 2E, 4E nonadienamide (II), N isobutyl 7 phenyl 2E, 4E heptadienamide(III)。结论　化合物I是新化合物,命名为大叶蒟素(laetispicine),化合物II和III为首次获得的天然产物。Aim To investigate the antidepressant constituents of Piper laetispicum C. DC. Methods The compounds were enriched by column chromatography on silica gel. Structural determination of the pure compounds was based on extensive analyses of modern spectroscopic methods including MS, HR-MS, UV, IR, 1D- and 2D-NMR spectra. The mouse forced swimming test was used for chasing antidepressant activity. Results Three amides were isolated and identified as N-isobutyl-(3,4-methylendioxyphenyl)-2E,4E,9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E,4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E,4E-heptadienamide (III). Conclusion N-Isobutyl-(3,4-methylendioxyphenyl)-2E,4E,9E-undecatrienoamide (I) is a new compound named as laetispicine. N-Isobutyl-9-phenyl-2E,4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E,4E-heptadienamide (III) were isolated for the first time as natural substance.

关 键 词：胡椒科 大叶蒟 大叶蒟素 酰胺类化合物 抗抑郁 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]