BALB/c-nu裸小鼠人胰腺癌模型声像图特点  

Ultrasonographic characteristics of implanted human pancreatic cancer on BALB/c hairless mice

作　　者：邓伟[1] 卓忠雄[1] 刘容[1] 朱铭[1] 

机构地区：[1]第三军医大学新桥医院超声科,400037

出　　处：《临床超声医学杂志》2005年第2期85-87,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的　为荷瘤裸小鼠胰腺癌模型实验研究提供新的观察方法。方法　建立BALB/c -nu裸小鼠种植性人胰腺癌动物模型,利用高频超声观察肿瘤结节生长特征及声像图特征。结果　接种后5～10d肿瘤持续快速生长,声像图呈低回声结节,界清无包膜,观察45d未见液化坏死;彩色血流信号显示率高,血供丰富。结论　高频超声显像可作为种植性人胰腺癌形态学观测的可靠指标之一。Objective To study the ultrasonographic imaging characteristics of implanted human pancreatic cancer on BALB/c hairless mice. Methods An animal model of implanted human pancreatic cancer on BALB/c hairless mice was established, and it was assessed by two-dimensional (2D) and color Doppler flow imaging (CDFI) techniques using high-frequency ultrasound every 5 days. The growth rate and its imaging characteristics of tumor lesions were analyzed. Results 5 to 10 days after implantation, the tumor of pancreatic cancer grew fast and continuously. The tumor appearred to be poor echo lesions with clear boundary in 2-D images. No necrosis or liquefaction was found within 45 days. CDFI showed that the tumor vasculature was rich. Conclusion Ultrasonography is a practical and reliable method for monitoring implanted pancreatic cancer on hairless mice.

关 键 词：人胰腺癌 BALB/C 声像图特点 彩色血流信号 高频超声显像 荷瘤裸小鼠 声像图特征 低回声结节 形态学观测 观察方法 实验研究 动物模型 方法建立 生长特征 超声观察 快速生长 液化坏死 接种后 显示率 种植 肿瘤 

分 类 号：R735.9[医药卫生—肿瘤] R392.12[医药卫生—临床医学]