大鼠纹状体血管构筑及增龄变化  

Angioarchitecture and aging changes of microvasculature in rat corpus striatum

作　　者：朱星红[1] 张春燕[2] 

机构地区：[1]第三军医大学解剖学教研室,重庆400038 [2]海军总医院老干部病房

出　　处：《解剖学杂志》2005年第2期201-204,共4页Chinese Journal of Anatomy

摘　　要：目的:研究纹状体血管构筑及其微血管的增龄变化,为探讨纹状体易卒中机制、揭示脑血管病发病机理提供参考资料。方法:运用墨汁明胶灌注、血管铸型、透明、透射电镜等方法观测了三组不同月龄Wistar大鼠纹状体的血管。结果:大鼠纹状体主要由颈内动脉、大脑中动脉、大脑前动脉供血,它们的中央支多以直角发出。尾壳核内部微血管网稠密,与神经纤维、神经细胞之间形成蜂巢状结构。苍白球血管网较稀疏,内囊血管网较苍白球更为稀疏,三者间界限清晰。>24月龄大鼠纹状体毛细血管基膜增厚、内皮细胞固缩、线粒体、内质网等细胞器减少。结论:大鼠纹状体的血供与人的相似,其特殊的形态及增龄变化可能与该区易发生脑血管病有关。Objective: To study the angioarchitecture and aging changes of microvasculature in rat corpus striatum, providing reference for further understanding of the etiology and pathogenesis of certain cerebrovascular diseases.Methods:The angioarchitecture of corpus striatum microvasculature in 3 different age groups of rat (1-2, 6-7, >24 months old) were studied and determined by ink-gelatin injection, corrosion casts, transparency and electron microscope technique.Results:The rat corpus striatum was mainly supplied by recurrent vessels from anterior cerebral artery, branches from the internal carotid artery and lenticulostriate artery. The main arteries set off central branches at right angle. The vascular network of caudatoputamen (CP) was dense. The vascular network and neurons formed honeycomb structures. The vascular network was thin and loose in globus pallidus (GP), and the thinnest and loosest was in internal capsule. The bounds among these 3 portions were clear. The aging changes of the rat corpus striatum capillary included basement membranes thickening, endothelial cells degeneration and organellae loss and atrophy. Conclusion:The arterial arrangement in rat corpus striatum is similar to that in human. The special morphology and aging changes of these vessels may have important implications for pathogenesis of cerebrovascular diseases in this region.

关 键 词：增龄变化 血管构筑 纹状体 Wistar大鼠 脑血管病 大脑中动脉 发病机理 血管铸型 不同月龄 透射电镜 颈内动脉 动脉供血 微血管网 神经纤维 神经细胞 基膜增厚 毛细血管 内皮细胞 苍白球 中央支 尾壳核 4月龄 线粒体 细胞器 

分 类 号：R743[医药卫生—神经病学与精神病学]