胃腺癌组织层粘连蛋白受体表达的意义  

Expression and significance of laminin receptor in gastric adenocarcinoma

作　　者：刘丽华[1] 王士杰[2] 单保恩[2] 郝国桢[3] 高建国[1] 张召[1] 

机构地区：[1]承德医学院附属医院肿瘤科,河北省承德市067000 [2]河北省肿瘤研究所,河北省石家庄市050011 [3]河北医科大学第二医院内科,河北省石家庄市050000

出　　处：《世界华人消化杂志》2005年第5期644-647,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨LN-R在判断胃腺癌浸润转移及预后中的作用方法:应用免疫组织化学S-P法检测76例胃腺癌组织和10例正常胃组织中LN—R的表达水平,比较LN—R的不同表达率与生存率的关系. 结果:LN—R在胃腺癌组织中阳性表达率为51.3%,较正常组织(10.0%)显著增高(P<0.05),与分化程度、Borrmann分型、浸润深度、肿块大小、淋巴结转移程度比较关系显著(X2=10.606、9.979、6.838、7.611、12.509,P<0.05),LN-R阳性表达者的生存时间较阴性者短(X2=9.980,P<0.05).AIM: To determine the expression of laminin receptor (LN-R) in gastric adenocarcinoma and its clinicopathological significance. METHODS: Immunohistochemical staining was performed on 76 cases of paraffin-embedded gastric adenocarcinoma tissues and 10 normal gastric mucosa tissues with mouse-anti-human LN-R polyclonal antibodies. RESULTS: The expression of LN-R in gastric adenocarcinoma was significantly higher than that in normal gastric mucosa tissues (P<0.05). The expression was significantly associated with differentiation degree, Bgrrmann stage, invasion depth, tumor size and lymphatic node metastasis (X2= 10.606, 9.979, 6.838, 7.611, 12.509, P<0.05). The positive expression was negatively correlated with the survival time (X2= 9.980, P<0.05). CONCLUSION: LN-R might act as an important index for judging the invasiveness, metastasis and prognosis of gastric adenocarcinoma.

关 键 词：腺癌组织 层粘连蛋白 受体表达 BORRMANN分型 淋巴结转移程度 癌浸润转移 免疫组织化学 阳性表达率 正常组织 分化程度 浸润深度 肿块大小 生存时间 LN 胃组织 生存率 预后 胃腺 

分 类 号：R735.2[医药卫生—肿瘤]