结合四环素和抗炎剂的牙周治疗对早发性牙周炎抗牙龈卟啉菌抗体水平的影响  

Effect of tetracycline combined with anti-inflammation drug a nd tetracycline on the level of serum IgG antibody titer in early-onset periodonti tis

作　　者：张秀琴[1] 黄世光[1] 张颖[1] 吕芳丽 

机构地区：[1]暨南大学医学院口腔系 [2]Laboratory of Malaria and Vector Research,National Institute of Allergy and Infectious Diseases,National Institutes of Health,Bethesda,MD20892-0425,USA

出　　处：《中国病理生理杂志》2005年第4期768-771,共4页Chinese Journal of Pathophysiology

基　　金：广东省医学科学研究基金资助项目 (No .A2 0 0 335 8)

摘　　要：目的:评价结合四环素和抗炎剂的牙周治疗对早发性牙周炎抗牙龈卟啉菌抗体IgG水平的影响。方法:研究对象由12名早发性牙周炎患者、16名成年牙周炎患者和12名牙周健康者组成。牙周炎患者接受常规牙周治疗,并口服四环素和消炎痛,牙周治疗前及治疗3个月后常规临床检查、记录牙周探诊深度和牙周附着水平及牙周探诊出血指数,并测定治疗前后患者血清抗牙龈卟啉菌抗体IgG滴度的变化。结果:牙周治疗后,牙周探诊深度、附着水平和牙周出血指数均有显著改善,血清抗牙龈卟啉菌抗体滴度明显下降。结论:结合四环素和消炎痛的机械性牙周治疗对早发性牙周炎可获得满意的疗效。血清抗牙龈卟啉菌抗体水平对评估早发性牙周炎的预后具有重要意义。AIM: The purpose of this study was to eva lu ate the effect of tetracycline combined with anti-inflammation drug on the serum antibody level against porphyromonas gingivalis (Pg) in patients with early-ons et periodontitis (EOP). METHODS: The study population consisted of 12 individuals with e arly-onset periodontitis, 16 patients with adult periodontitis (AP) and 12 perio dontally healthy subjects (HS). Clinical examination and recordings of probing p ocket depth (PPD), periodontal attachment level (PAL) and bleeding on probing (B OP) were performed prior to treatment and at three months following the periodontal treatment. The serum antibody titer against Pg in patients with EOP was measured at diagnosis and at the termination of treatmeat. RESULTS: A significant improvement was observed in probing pocke t depth, periodontal attachment level and gingival bleeding index post treatment for three months. The serum IgG antibody titer against porphyromonas ging ivalis was decreased significantly after the treatment. CONCLUSION: Our results demonstrate that mechanical periodontal treatment combined with tetracycline and anti-inflammation drug provides clinica lly favorable results in patients with early-onset periodontitis.

关 键 词：牙周炎 紫单胞菌 龈 抗体 四环素类 

分 类 号：R363[医药卫生—病理学]