己酮可可碱对小鼠TNBS结肠炎的药效学研究  

Effect of pentoxilylline on murine TNBS colitis model

作　　者：张炳勇[1] 吕愈敏[2] 洪天配[2] 李军[2] 张玲[2] 董秀云[2] 

机构地区：[1]河南省人民医院消化科,郑州450003 [2]北京大学第三医院消化科

出　　处：《胃肠病学和肝病学杂志》2005年第2期145-146,149,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(30040022);国家教委博士点基金(200017)

摘　　要：目的观察己酮可可碱(PTX)对小鼠TNBS(三硝基苯磺酸)肠炎的作用。方法通过直肠给予雄性BALB/c小鼠TNBS诱导结肠炎,应用PIX对其进行治疗,6日后收集结肠标本评价结肠炎症程度。结果直肠内给予BALB/c小鼠TNBS后可造成小鼠结肠炎性改变PTX治疗可使小鼠疾病活动指数、结肠重量和炎症指数均显著下降(P <0 0 5 )。结论PTX治疗可使TNBS肠炎模型小鼠肠道炎症减轻。Objective To investigate the roles of pentoxifylline (PTX) on the murine TNBS (2,4,6-trinitrobenzene sulfonic acid) model of intestinal inflammation.Methods Colitis was induced in BALB/c mice by rectal administration of TNBS in ethanol. Mice were treated with pentoxifylline, and the samples of colon were harvested 6 days after treatment for evaluating colonic inflammation.Results Intrarectal administration of TNBS to BALB/c mice resulted in colon inflammation. PTX treatment significantly reduced TNBS-induced disease activity index(DAI), colon weight and total colitis score.Conclusion PTX treatment could attenuate intestinal inflammation of TNBS colitis.

关 键 词：TNBS肠炎 己酮可可碱 2 4 6-三硝基苯磺酸 治疗 

分 类 号：R574[医药卫生—消化系统]