TA方案在局部晚期乳腺癌的治疗研究  

The analysis of taxol and ADM in local advanced breast cancer

作　　者：方万强[1] 吴瑞景[1] 邓国敏[1] 傅春利[1] 

机构地区：[1]广东省开平市中心医院胸科,529300

出　　处：《广州医药》2005年第2期55-56,共2页Guangzhou Medical Journal

摘　　要：目的探讨TA(泰素加阿霉素)化疗方案在局部晚期乳腺癌(T3N1M0除外)综合治疗中临床价值。方法用TA方案对28例局部晚期病人进行新辅助化疗2个疗程。结果28例中,完全缓解(CR)4例(14.3%),部分缓解(PR)22例(78.5%),无效(NC)1例(3.6%),进展(PD)1例(3.6%),总有效率92.8%。主要不良反应为消化道症状28例,脱发28例,心脏毒性2例,过敏反应11例,骨髓抑制4例,发热6例,头晕3例,肝功能异常1例。结论TA方案在局部晚期乳腺癌新辅助化疗中有较好疗效,临床应用毒性反应可耐受。Objective To investigate the clinical value of TA (combined Taxol and ADM) chemotherapy in the associated treatment of local advanced breast cancer. Methods 28 patients with local advanced breast cancer were treated by two courses of Taxol and ADM as neoadjuvant chemotherapy. Results There were 22 cases of CR (14.3%),22 cases of PR(78.5%),one case of NC (3.6% and only one case of PD(3.6%), the total effective rate of 92.8%.Main side affects included digestive symptoms in 28 cases,hair loss in 28 cases,cardiotoxicity in 2 cases,hypersensitiviness in 11 cases,inhibition of bone marrow in 4 cases,fever in 6 cases,dizziness in 3 cases and liver function damage in 1 cases. Conclusion Taxol and ADM has a good effect in local advanced breast cancer as neoadjuvant chemotherapy.The clinical toxicity can be tolerated.

关 键 词：局部晚期乳腺癌 TA方案 新辅助化疗 消化道症状 肝功能异常 临床价值 综合治疗 化疗方案 晚期病人 完全缓解 总有效率 不良反应 心脏毒性 过敏反应 骨髓抑制 毒性反应 临床应用 阿霉素 

分 类 号：R737.9[医药卫生—肿瘤] R733.71[医药卫生—临床医学]