Isolation and pharmacological activities of bromophenols from Rhodomela confervoides  

作　　者：韩丽君 徐年军 石建功 严小军 曾呈奎 

机构地区：[1]Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China [2]Institute of Marina Medica, Chinese Academy of Medical Sciences, Beijing 100050, China [3]Key Laboratory of Marine Biotechnology, Ningbo University, Ningbo 315211, China

出　　处：《Chinese Journal of Oceanology and Limnology》2005年第2期226-229,共4页中国海洋湖沼学报（英文版）

基　　金：Supported by National "863" Program (No. 2004AA625030, 2001AA620503), Qingdao marine sciences project (No. 04-2-NN-26) and Key Knowledge Innovative Project of the Chinese Academy of Sciences (KZCX3-SW-215).

摘　　要：Four bromophenols were isolated from the extract of marine red alga, Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods including IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities against Staphylococcus aurens and Pseudomonas aeruginosa.Four bromophenols were isolated from the extract of marine red alga, Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods including IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities against Staphylococcus aurens and Pseudomonas aeruginosa.

关 键 词：Rhodomela confervoides bromophenol ANTITUMOR ANTIBACTERIAL 

分 类 号：R285[医药卫生—中药学]