事件相关电位对甲状腺功能亢进患者智能障碍的评估价值  

Event related potential for the evaluation of intellectual dysfunction in patients with hyperthyroidism

作　　者：汪洪[1] 李云玫[1] 王琳[1] 刘诗翔[1] 舒子正[2] 

机构地区：[1]解放军成都军区昆明总医院神经内科,云南省昆明市650032 [2]解放军成都军区昆明总医院内分泌科,云南省昆明市650032

出　　处：《中国临床康复》2005年第12期50-51,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:探讨甲状腺功能亢进患者是否存在高级神经功能障碍。方法:2003-01/11解放军成都军区昆明总医院的住院甲状腺功能亢进患者35例,采用韦氏成人智力量表和事件相关电位对此35例患者和31例健康对照者进行测试。结果:患者组除数字符号分测验外,其余各项智力分测验成绩明显低于对照组(P<0.01);77%(27/35)的患者有不同程度的智力障碍;发现5项操作分测验中有4项两组间有显著统计学差异;患者组P2,N2和P3的潜伏期较对照组显著延长(P<0.01)。结论:甲状腺功能亢进患者存在有不同程度的高级神经功能障碍。AIM:To probe into the existence of advanced nervous dysfunction in patients with hyperthyroidism. METHODS:Totally 35 patients with hyperthyroidism were admitted in General Hospital of Chengdu Military Aarea Command of Chinese PLA from Kunming January to November 2003.The 35 patients and 31 healthy controls were tested with Wechsler adult intelligence scale(WAIS) and event related potential. RESULTS:The achievements of WAIS in the patient group were significantly lower than those in control group(P< 0.01),except digit symbol test.The different grade intellectural dysfunction existed in 77%(27/35) of patients.There was significant difference in the four items of five manipulative tests between the two groups.The latent period was significantly prolonged in P2,N2 and P3 in the patient group as compared with that in control group(P< 0.01). CONCLUSION:The patients with hyperthyroidism have advanced nervous dysfunction in different degree.

关 键 词：甲状腺功能亢进 事件相关电位 P300 韦氏智力量表 智力 

分 类 号：R749.05[医药卫生—神经病学与精神病学]