汉语阅读障碍儿童脑血流改变与阅读技能测试的关系(英文)  

Relationship between the change of brain blood flow and reading skill test in children with Chinese reading disorder

作　　者：吴永刚[1] 马琦琳[2] 杨志伟[3] 何建军[1] 刘国锋[1] 支科[1] 

机构地区：[1]中南大学湘雅二医院核医学科,湖南省长沙市410011 [2]中南大学湘雅医院心内科,湖南省长沙市410007 [3]中南大学湘雅二医院精神卫生研究所,湖南省长沙市410011

出　　处：《中国临床康复》2005年第12期236-238,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:阅读障碍是儿童障碍的主要类型,目前人们尚不明了病因、病理机制。目的:探讨儿童汉语阅读障碍的脑血流改变与阅读技能诊断测试评分的相关性,以期为阅读障碍患儿的早期干预和功能监测提供理论参考。设计:以阅读障碍患儿为研究对象,正常儿童为对照组的观察对比研究。单位:一所大学医院的核医学科及精神卫生研究所。对象:本研究由中南大学湘雅二医院核医学科及精神卫生研究所共同完成。于1998-08/1999-08在长沙市2所小学3～6年级学生中筛查出阅读障碍儿童25例作为阅读障碍组,男15例,女10例,年龄(10±1)岁。纳入标准:①根据教师评价有语文学习困难持续1年以上,学习困难发生于学龄早期(三年级以前),学习成绩在班上一直居后或考试经常不及格或因学习困难留级者;②课堂、家庭作业独立完成困难者;③家长、教师评定、作业调查与临床检查符合阅读障碍的国际疾病分类第10版诊断标准者;④阅读技能诊断测试评定阅读技能障碍者;⑤智商测验IQ≥70者。排除标准:①视听觉障碍者;②明显的情绪障碍、多动症及器质性脑病患者。在阅读障碍患儿所在班级随机抽取身心健康、智力测验正常的儿童20例作为对照组,男12例,女8例,年龄为(10±1)岁。方法:用非采血法单光子发射计算机断层摄影术显像测定阅读障碍患儿和正常对照者全?BACKGROUND:Reading disorder is the main obstacle in children, but its etiolog y and pathogenesis are still uncovered. OBJECTIVE:To explore the relationship between brain blood flow (BBF) and score s for children reading skill detecting test (CRSDT),in order to provide theoreti cal references for earlier intervention and functional monitoring for children w ith reading disorder(RD). DESIGN:Comparative observation study with RD children as subjects and normal c hildren as control SETTING:Nuclear medicine and psychological health institute of a university. PARTICIPANTS:This study was carried out in Nuclear Medicine and Psychological health Institute of Second Xiangya Hospital,Central South University.Between A ugust 1998 and August 1999,25 children with RD were screened out from the studen ts from grade 3 to grade 6 in two Changsha civic elementary schools,including 15 males and 10 females aged(10±1)years.Inclusion criteria:①Chinese learning difficulty proved by their teacher lasted for more than one year and began from the earlier stage of school age(before grade three),with their achievement ra nked last or often failed in examinations,even stay in the same grade due to lea rning disorder;②Difficult to do homework independently;③Evaluation by their parents and teacher or investigation of their homework accorded to the ICD 10 d iagnostic standards of RD;④CRSDT assessment for children with RD;⑤Intelligen ce quality (IQ)≥70.Exclusion criteria:①Visual auditory disorder;②Obvious e motional obstacle,hyperkinetic syndrome and organic brain diseases.Meanwhile 20 healthy children with normal intelligence were randomly selected as control grou p from the same class of RD children,including 12 males and 8 females with age of (10±1)years. METHODS:Non blood sampling SPECT images was used for detecting cerebral blood flow(CBF),as well as right and left CBF and regional CBF(rCBF)of both RD ch ildren and normal controls. Rough scores for CRSDT were obtained for analyzing t he relationship between it and CBF. MAI

关 键 词：阅读障碍 脑血管循环 体层摄影术 发射型计算机、单光子 

分 类 号：R749.94[医药卫生—神经病学与精神病学]