沙门氏菌感染的免疫应答  

The Innate Immune Response to Salmonella

作　　者：潘志明[1] 黄金林[1] 唐丽华[1] 焦新安[1] 

机构地区：[1]扬州大学生物科学与技术学院,江苏扬州225009

出　　处：《动物医学进展》2005年第4期41-44,共4页Progress In Veterinary Medicine

基　　金：国家 863 计划( 2002AA245051 );国家自然科学基金资助项目( 30170700 );江苏省自然科学基金(BK2003043)

摘　　要：巨噬细胞、中性粒细胞和树突状细胞等吞噬性细胞在对沙门氏菌感染的天然免疫应答过程中发挥着重要作用。在细菌感染的早期,这些细胞的数量增多,控制细菌的繁殖,并分泌产生细胞因子和趋化因子。感染沙门氏菌后,自然杀伤细胞、自然杀伤T细胞和TCRαβT细胞也会对感染发生迅速反应,且是γ干扰素的早期细胞来源。文章着重探讨了沙门氏菌感染天然免疫应答的细胞分子机理,为沙门氏菌病的预防控制提供新认识。Phagocytic cells, including macrophages, neutrophils and dendritic cells, are critical components of the innate immune response to Salmonella.These cells can have several roles during the early stage of an infection including controlling bacterial replication and producing cytokines and chemokines that activate and recruit additional cells. Macrophages, neutrophils and dendritic cells increase in number early after oral Salmonella infection.Natural killer cells, natural killer T cells and T cell receptor αβ T cells also respond rapidly to infection and are early sources of interferon-γ during infection with Salmonella.Studies using infection models with Salmonella are providing a picture of the innate response to bacteria and insight into the role of defined cell types and cytokines important in the transition from innate to adaptive immunity.

关 键 词：沙门氏菌 天然免疫应答 细胞分子机理 

分 类 号：S852.612[农业科学—基础兽医学]