基质金属蛋白酶-9在喉癌中的表达及意义  

Expression of Matrix Metalloproteinase-9 and Its Significance in Laryngeal Squamous Cell Carcinoma

作　　者：傅莉萍[1] 卢义生[1] 

机构地区：[1]广东省东莞市人民医院病理科,广东东莞523018

出　　处：《赣南医学院学报》2005年第1期64-66,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨基质金属蛋白酶- 9(matrixmetalloproteinase - 9,MMP - 9) ,在喉鳞癌中的表达及其临床意义。方法:运用免疫组织化学二步法检测喉癌组织和其相邻的正常黏膜组织中的MMP - 9的表达。结果:4 0例喉癌组织中的MMP - 9阳性表达率为90 .0 % ,MMP - 9在喉癌组织中与癌旁正常黏膜的阳性表达差异明显(P <0 .0 1) ;发生颈淋巴结转移组的强阳性表达率明显高于无淋巴结转移组(P <0 .0 1) ;MMP - 9在晚期喉癌中表达增高,临床分期Ⅲ～Ⅳ期强阳性表达率明显高于Ⅰ～Ⅱ期(P <0 .0 1) ,深部浸润的癌巢及基底膜附近的肿瘤细胞染色尤为明显。结论:MMP - 9与喉癌的浸润和淋巴结转移有关。Objective:To investigate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in laryngeal squamous cell carcinoma. Methods:Two-step immunohistochemical method was used to examine the expression and location of MMP-9 in the tissue of 40 cases laryngeal cancer and their surrounding normal mucosa. Results:It was found that the positive rate of MMP-9 in 40 laryngeal cancer tissues was 90.0%(36/40),the difference of the expression of MMP-9 in tumor tissue and normal mucosa beside the tumor was significant(P<0.01).The positive rate in those carcinoma with cervical lymph node metastasis was much higher than that in cases without cervical lymph node metastasis(P<0.01).The positive rate in the clinical stage Ⅲ～Ⅳ of these patients was higher than the clinical stageⅠ～Ⅱ(P<0.01). MMP-9 was immunolocalized on the membrane and intracytoplasm of metastatic cluster tumor cells or the tumor cells adjacent to the basement membrane. Conclusion:The results showed that the expression of MMP-9 has relationship to invasion and lymph node metastasis of laryngeal squamous cell carcinoma.

关 键 词：喉肿瘤 基质金属蛋白酶 

分 类 号：R739.65[医药卫生—肿瘤]