腺苷参与弱电针对大鼠脊髓背角神经元伤害性放电的抑制  

Role of Adenosine in Weak Electro-acupuncture-induced Depression of Nociceptive Response of Spinal Dorsal Horn Neurons in Rats

作　　者：刘长宁[1] 赵飞跃[1] 李文武[1] 朱丽霞[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1994年第2期52-55,共4页Acupuncture Research

摘　　要：在脊髓横断大鼠，以腰髓背角广动力型（WDR神经元）的伤害性放电为指标，观察弱电针对WDR神经元的抑制作用及静注腺苷受体阻断剂对其的影响。用50Hz，1．0～1．5mA的连续波电针″阳陵泉″-″悬钟″后，WDR神经元的伤害性放电减少，茶碱和咖啡因可阻断电针的抑制效应。提示弱电针可抑制脊髓背角神经无伤害性反应，腺苷可能参与此抑制过程。In this study, extracellular recordings were made from wide dynamic range (WDR) neurons in lumbar segments of the spinal cord in rats transsected at the first lumbar segment. The nociceptive discharges of WDR neurons were depressed by weak electro-acupuncture applied to ″Yanglingquan″-″Xuanzhong″ points. The depression was blocked by i. v. administration of adenosine receptor antagonists, theophylline and caffeine. The observations indicate that depression of the nociceptive response of the WDR neurons induced by weak EA may be mediated by adenosine within the spinal cord.

关 键 词：电针疗法 广动力型 神经元 茶碱 咖啡因 

分 类 号：R245.97[医药卫生—针灸推拿学]