茶黄素对Ox-LDL诱导单核内皮细胞粘附作用影响的研究  

Study on the Effect of Theaflavins on the Adhesion between Monocyte and Endothelial Cells

作　　者：吕虎[1] 华萍[2] 余继红[1] 蒋显猷 冷和平 

机构地区：[1]江西师范大学生命科学学院,南昌330000 [2]江西医学院基础部,南昌330000 [3]江西绿色制药有限公司,南昌330027

出　　处：《中药材》2005年第4期304-306,共3页Journal of Chinese Medicinal Materials

基　　金："九五"科技攻关计划"1035"工程项目;项目编号:96 901 05 277

摘　　要：采用硫酸铜诱导低密度脂蛋白(LDL)氧化,细胞粘附实验,细胞ELISA方法测定内皮细胞间粘附因子(ICAM- 1)和血管内皮细胞粘附因子(VCAM -1)表达水平,研究了茶黄素(TFs)对氧化型低密度脂蛋白(Ox- LDL)损伤血管内皮细胞导致单核细胞粘附的影响。结果显示,茶黄素(TFs)能显著抑制由Ox- LDL诱导的单核细胞血管内皮细胞粘附效应以及细胞间粘附因子(ICAM -1)和血管内皮细胞粘附因子(VCAM- 1)的表达,并呈现浓度剂量正相关性。提示,TFs抑制ICAM -1和VCAM -1的表达是其抑制单核内皮细胞粘附和抗动脉粥样硬化的作用机制之一。The effect of theaflavins (TFs) on the adhesion between monocyte and endothelial cells induced by oxidized low density lipoprotein was studied. The experiments of cells-adhesion,the cells ELISA were applied.The results showed that TFs could significantly inhibit the adhesion between monocyte and endothelial cells,and the expression of cell adhesion molecule (ICAM-1) and vescular cell adhesion molecule (VCAM-1).That maybe one of the mechanisms in antiatheroclerosis and antiadhesion between monocyte and endothelial cells.

关 键 词：OX-LDL诱导 细胞粘附作用 茶黄素 影响的研究 氧化型低密度脂蛋白 单核-内皮细胞粘附 血管内皮细胞粘附 细胞粘附因子 ELISA方法 抗动脉粥样硬化 单核细胞粘附 VCAM-1 ICAM-1 作用机制 硫酸铜 抑制 相关性 

分 类 号：R543.4[医药卫生—心血管疾病] R965[医药卫生—内科学]