p16^(INK4)、p21^(ras)及p185^(C-erbB-2)蛋白在子宫内膜癌的表达及临床病理意义  

The Clinicopathologic Significance of p16^(INK4)、p21^(ras) and p185^(C-erbB-2) Protein Expression in Endometrial Carci noma

作　　者：徐少婷[1] 郑艳[1] 滕晓东[1] 苏玲娣[2] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003 [2]南通医学院第二附属医院,江苏南通226001

出　　处：《实用妇产科杂志》2005年第4期220-222,i001,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:研究p16 INK4 蛋白在子宫内膜增殖症和子宫内膜癌的表达特征,以探讨其与p2 1ras、p185 C erbB 2 蛋白的相互关系及在子宫内膜癌发生发展中的作用。方法:应用免疫组化SP法检测6 5例子宫内膜癌及2 0例子宫内膜增殖症组织中p16 INK4 、p2 1ras及p185 C erbB 2 蛋白的表达。结果:子宫内膜增殖症组织p16 INK4 蛋白表达率为85 .0 0 % (17/ 2 0 ) ,子宫内膜癌组织p16 INK4 蛋白表达率为6 0 .0 0 % (39/ 6 5 ) ,其表达与组织分级及p185 C erbB 2 蛋白表达呈负相关。结论:p16 INK4 蛋白失表达与子宫内膜癌分化差有一定关系,与p2 1ras、p185 C erbB 2 蛋白的联合检测可反映肿瘤的分化。Objective: To study the expression and it 's clinicopathologic signifi cance of p16 INK4 protein in hyperplastic endometria and endometrial carcin omas, and to evaluate the relationship among p16 INK4, p21 ras and p18 5 C-erbB-2 proteins. Methods: The expression of p 16 INK4, p21 ras and p185 C-erbB-2 proteins were stud ied in 65 cases with endometrial adenocarcinoma and 20 cases of hyperplastic end ometria by Immunohistochemical methods (SP).Results: The expressive rates of p16 INK4 protein was 85.00%(17/20)in hyperplasti c endometria, and 60.00%(39/65)in endometrial carcinoma, respectively. The e xpression of p16 INK4 was ne gatively correlated to the histologic grade of the tumor and the over-expression of p185 C-erbB-2. Conclusions: The loss of p16 INK4 expression might be an importa nt marker of poor-differentiation of endometrial carcinoma. The expression of p1 6 INK4 protein combined with p21 ras and p185 C-erbB-2 proteins can aid to predict the differentiation of endometrial carcinoma.

关 键 词：子宫内膜癌 p16^INK4蛋白 P21^RAS蛋白 p185^C-erbB-2蛋白 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]