成人急性B淋巴细胞白血病核型t(9;22)易位与免疫表型关系探讨  

The relationship of immunophentyping and karyotype t(9;22) translocation associated with adult B cell acute lymphoblastic leukemia

作　　者：朱明清[1] 陈黎[1] 耿美菊[1] 吴亚芳[2] 阮长耿[2] 

机构地区：[1]苏州大学核医学生物技术重点实验室,215007 [2]苏州大学附属第一医院江苏省血液研究所,215007

出　　处：《白血病．淋巴瘤》2005年第2期90-91,共2页Journal of Leukemia & Lymphoma

摘　　要：目的探讨成人急性B淋巴细胞白血病(B蛳ALL)染色体t(9;22)易位与免疫表型之间的关系。方法对154例初治成人B蛳ALL进行形态学(M)免疫学(I)和细胞遗传学(C)分型。结果发现有t(9;22)易位(Ph+)的B蛳ALL占46例(29.9%),其中伴髓系抗原(CD13或CD33表达(My+)有28例(60.9%),伴T细胞抗原(CD2或CD3或CD13)表达(T细胞抗原阳性)3例(6.5%),CD3+439例(84.8%),CD1+045例(97.8%)。经分析发现,Ph+与My+高度相关,而与T细胞抗原和CD3+4无相关。结论伴髓系抗原表达的成人B蛳ALL与核型t(9;22)易位密切相关。这可能是影响成人My+B蛳ALL缓解率低,持续缓解时间短,预后差的原因之一。Objective To find out the relationship of karyotype t(9;22) translocation and immunophenotype associated with adult B cell acute lymphoblastic leukemia (B- ALL). Methods MIC typing was performed in 154 adult B- ALL. Results The incidence of myeloid- associated antigen (CD13, CD33) expression was higher in Ph positive cases than Ph negative B- ALL. There were no difference in the expression of CD34 or T lymphoid antigen between Ph positive cases and Ph negative B- ALL cases. Conclusions My+ adult B cell acute lymphoblastic leukemia is significantly associated with the t(9;22) translocation.

关 键 词：急性淋巴细胞性白血病 MIC分型 髓系抗原 淋系抗原 t(9 22) 流式细胞术 

分 类 号：R733.7[医药卫生—肿瘤]