高原低氧对CNP、ET和CGRP血浆含量的影响  

Effect of High Altitude Hypoxia on Changes of Plasma CNP,ET and CGRP Contents in Healthy Young Males

作　　者：高芬[1] 周青玉[1] 张林彬[1] 华毛[1] 关巍[1] 

机构地区：[1]青海大学附属医院呼吸科,810001

出　　处：《放射免疫学杂志》2005年第2期101-103,共3页Journal of Radioimmanology

摘　　要：目的:探索高原低氧对C型利钠肽、内皮素和降钙素基因相关肽血浆含量的影响。方法:采用放射免疫分析测定40名世居海拔1100m(对照组)的健康青年男性志愿者进入海拔2260m 3个月, 3780m 1d、5d和15d时血浆C型利钠肽(CNP)、内皮素(ET)和降钙素基因相关肽(CGRP)含量。结果: 1 方差分析结果:CNP血浆含量随海拔升高明显增加(海拔3780m15d组与前4组相比P<0 01)。ET进入海拔3780m5d时血浆ET含量显著减少(与海拔2260m相比P<0 01);随着在海拔3780m停留时间延长,ET含量显著增加(3780m 15d与前4组相比P<0 01),CGRP当志愿者进入海拔2260m3月时CGRP含量达峰值(与对照组相比P<0. 01),进入海拔3780m后其浓度持续下降, 15d时降至最低点(与海拔2260m相比P<0 01)。2 相关性分析:CGRP含量与ET呈负相关(r=-0 425,P<0 05);CNP含量与ET正相关(r=0.470,P<0. 01)。结论:ET、CGRP和CNP参与了人体肺循环对低氧的生理性调节,CGRP作用于缺氧初期肺循环的扩血管调节反应、ET和CNP含量则随缺氧时间延长和海拔升高增加。Objective To explore the changes of plasma CNP, ET and (CGR contents in healthy young males with exposure to high altitude hypoxia. Methods Plasma CNP, ET and CGRP contents were measured with RIA in 50 healthy young males at the altitude of 1000m (as control), 2260m (medium altitude) and 3780m (high altitude for 1d, 5d and 15d) successively. Results ①Plasma CNP contents increased gradually as the altitude rose (at high altitude for 15d vs all other 4 settings, P<0.01). ②Plasma ET contents were significantly lower at high altitude for 5d than those at medlum altitude, P<0.01. However, prolonged stay at high altitude for 15d would significantly increase the plasma ET contents (vs all other 4 settings, P<0.01). ③Plasma CGRP contents reached peak at medium altitude (vs medium altitude, P<0.01). ④Plasma ET contents were positively correlated with CNPcontents (r=0.470, P<0.01) but negatively correlated with CGRP contents (r=-0.425,P<0.05). Conclusion ET, CGRP and CNP participate in the physiologic regulation of pulmonary circulation under hypoxia. CGRP, a strong vaso dilator, modulates pulmonary vascular dilatation at the early stage of hypoxia. After prolonged exposure to high altitiude hypoxia ET and CNP contents increase significantly.

关 键 词：高原低氧 CNP ET CGRP 血浆含量 

分 类 号：R364.4[医药卫生—病理学]