肝细胞癌组织中endoglin(CD_(105))和VEGF及p57^(kip2)表达与预后的关系  

Relationship between expressions of endoglin(CD_( 105)), VEGF and p57 ^(kip2) in hepatocellular carcinoma and patient prognosis

作　　者：姚卫东[1] 姜惠峰[2] 曲桂梅[1] 于文方 王威[1] 姜蕾[1] 潘旭波[1] 郝俊梅[1] 

机构地区：[1]烟台市毓璜顶医院病理科,山东烟台264000 [2]烟台市莱阳中心医院病理科,山东莱阳265200

出　　处：《肿瘤防治杂志》2005年第5期360-364,共5页China Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨肝细胞癌(hepatocellular carcinoma, HCC) endoglin ( CD105 )、血管内皮生长因子( vascular endothelialgrowth factor, VEGF)和有丝分裂抑制因子(p57kip2)的表达与组织形态学和自然病程的关系。方法: SP 法检测143 例资料完整的HCC中63 例获访者肝癌组织和20例非肝癌肝组织中endoglin (CD105 )、VEGF和p57kip2 的表达。结果:肝癌组织endoglin(CD105)、VEGF和p57kip2 免疫组化阳性率分别为68 .3% ( 43/63 )、73 .0%(46/63)和68. 3%(43/63),显著高于癌旁组织及非癌肝组织,P=0. 000 0。癌组织分化与VEGF、endoglin (CD105)和p57kip2表达差异无统计学意义(P值分别为0 .097 8、0. 139 3 和0. 839 7 )。endoglin ( CD105 )、VEGF和p57kip2 表达不同,患者的生存时间有差别(P值分别为0 .001 3、0 .003 9和0 000 8), endoglin (CD105 )和VEGF高表达,可能预示预后较差,而p57kip2高表达可能预示预后较好。p57kip2 表达与endoglin(CD105)和VEGF表达呈负相关,r’s 值分别为-0. 357 2和-0 .272 5。结论:endog lin( CD105 )、VEGF 蛋白的过度表达和p57kip2丢失可能与肝癌的发展及预后有关。OBJECTIVE:To explore the relationship between expressions of endoglin(CD 105),vascular endothelial growth factor(VEGF),mitotic inhibitor/suppressor protein (p57 kip2) and histopathological profiles, natural history in human hepatocellular carcinoma (HCC). METHODS: The expressions of endoglin (CD 105), VEGF and p57 kip2 protein were assayed by using immunohistochemical staining (SP) in 63 HCC specimens from 143 consecutive cases and 20 noncarcinous liver specimons. RESULTS:The endoglin (CD 105),VEGF and p57 kip2 protein positive-expression rates in tumor tissue of HCC were 68.3% (43/63),73.0% (46/63) and 68.3% (43/63),respectively, which were significantly higher than those in adjacent liver tissue and non-carcerous tissue,P=0.000 0. Tumor differentiation was no statistical significance difference with expression of VEGF, endoglin (CD 105) and p57 kip2 ( P=0.097 8, 0.139 3, 0.839 7, respectively). Different expressions of endoglin (CD 105), VEGF and p57 kip2 protein were statistical significance difference with patient survival (P=0.001 3, 0.003 9, 0.000 8, respectively), high expressions of endoglin (CD 105) and VEGF protein could be prediction of poor patient survival, conversely those of p57 kip2 dad better survival. Expression of p57 kip2 protein had all negative correlation with endoglin (CD 105) and VEGF (r’ s=-0.357 2, -0.272 5, respectively). CONCLUSIONS: Overexpressions of endoglin (CD 105) and VEGF protein and the loss of expression of p57 kip2 protein in HCC may significantly relate to patient progress of HCC and patient prognosis.

关 键 词：癌 肝细胞病理学 膜-糖蛋白类 内皮生长因子 有丝分裂抑制因子 免疫 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]