TSGF,AFP,CEA,CA-50联合检测在肝癌诊断中的价值  

The Clinical Value of Combining TSGF,AFP,CEA and CA-50 Examination in the Diagnosis of Primary Hepatocellullar Carcinoma (PHC)

作　　者：张德奎[1] 杨燕[2] 马力[1] 张银枝[1] 

机构地区：[1]兰州医学院第二附属医院消化科,甘肃省兰州市730000 [2]甘肃省人民医院普内科

出　　处：《中国全科医学》2005年第8期625-626,共2页Chinese General Practice

摘　　要：目的评价肿瘤标记物肿瘤特异性生长因子(TSGF)、AFP、CEA、CA-50对肝癌的诊断价值以及联合检测的意义。方法对42例肝癌患者、30例良性肝病患者和30例健康体检者联合检测TSGF(比色法)、AFP、CEA、CA-50(均用放免法),并进行比较。结果肝癌患者与正常对照者的TSGF、AFP、CEA、CA-50水平间差别均有显著性意义(P<0.01);4项指标对肝癌诊断的敏感度分别为61.6%,69.0%,33.3%,23.8%,特异度分别为86.5%,83.3%,89.6%,90.4%;4项指标联合检测对肝癌诊断的敏感度可提高到91.2%,尤其对胆管细胞癌诊断有利。结论TSGF是一种敏感的肝癌标记物,TSGF,AFP,CEA,CA-504项指标联合检测可显著提高肝癌的检出率。Objective To evaluate the clinical value of combining TSGF,AFP,CEA and CA-50 examination in diagnose of primary hepatocellular carcinoma (PHC).Methods In 42 patients with PHC and 30 normal people (as control group),the serum TSGF was examined by colorimeter and serum AFP,CEA,CA-50 were examined by radioimmuney assay,and the comparison was done.Results The mean serum TSGF,AFP,CEA and CA-50 in PHC group was significantly higher than that in control group (P<0.01),the sensitivity of TSGF,AFP,CEA and CA-50 in diagnose of PHC was 61.6%,69.0%,33.3%,23.8% respectively while the specificity was 86.5%,83.3%,89.6%,90.4% respectively.The sensitivity could raise to 91.5% markedly when these four tumor markers were examined together,which is especially good for bile duct cell cancer diagnosis.Conclusion TSGF is a sensitive carcinoma marker and the detection of combining TSGF,AFP,CEA and CA-50 can improve the accurate rate effectively.

关 键 词：CA-50 联合检测 TSGF 肝癌诊断 AFP CEA 肿瘤特异性生长因子 肝癌患者 肿瘤标记物 健康体检者 胆管细胞癌 诊断价值 肝病患者 正常对照 癌标记物 敏感度 比色法 放免法 显著性 指标 特异度 检出率 

分 类 号：R735.04[医药卫生—肿瘤] R734.2[医药卫生—临床医学]