凋亡抑制蛋白survivin在垂体腺瘤中的表达  

Expression of apoptosis regulatory protein survivin in pituitary adenomas

作　　者：申培红[1] 马杰[2] 陈奎生[3] 张云汉[3] 

机构地区：[1]郑州市中心医院病理科,450007 [2]河南省肿瘤医院病理科 [3]郑州大学医学院病理学教研室

出　　处：《中华内分泌代谢杂志》2005年第2期144-145,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用免疫组织化学法检测survivin、bcl- 2蛋白在8例正常垂体组织及38例垂体腺瘤组织中的表达。结果提示survivin蛋白的表达阳性率与垂体腺瘤组织中的bcl -2蛋白表达密切相关,survivin蛋白表达异常引起的细胞凋亡抑制在垂体腺瘤的发生中起一定作用。The expressions of survivin and bcl-2 protiens were examined in 8 specimens from normal pituitary tissues and 38 pituitary adenomas by immunohistochemistry. The results showed that the expression of survivin was strongly associated with bcl-2 expression and abnormal expression of survivin resulted in inhibition of cell apoptosis, which might play a role in the pathogenesis of pituitary adenomas.

关 键 词：凋亡抑制蛋白 SURVIVIN 垂体腺瘤 基因表达 免疫组织化学 

分 类 号：R736.4[医药卫生—肿瘤]