小儿急性感染性多发性神经根炎抗髓磷脂碱蛋白抗体的测定及意义  

The levels of MBPAb on children with GBS

作　　者：贾永恒[1] 李天云[1] 李海波[1] 王文志[1] 

机构地区：[1]白求恩医大一院儿科,白求恩医大三院内一科

出　　处：《中风与神经疾病杂志》1994年第1期19-21,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：作者测定了６４例急性多发性神经根炎患儿的血和脑脊液中髓磷脂碱蛋白抗体，并与５０例正常儿童进行了比较。结果表明：患儿的血和脑脊液中该抗体明显高于正常对照组；混合型病例不论是血中还是脑脊液中存在的该抗体明显高于脊神经型病例；患儿血中和脑脊液中存在的该抗体具有明显相关性。提示：该抗体在本病发病中可能占重要地位；抗体的存在与疾病的严重性有关；脑脊液中该抗体可能来源于外周血。由此进一步推测。本病脑脊液中增高的蛋白质亦可能来源于外周血。Abstract Gullian Barrie Syndrome(GBS) is a common nervous system disease in China,specially in the young and children.It belongs to autoimmune demyelinative disease in peripheral nervous system.We measured the levels of GBS's autoantibodies including Myelin Bassic Protein Antibody(MBPAb).The results showed that the levels of MBPAb in GBS patients were significantly higher than those in normal control group.It is demonstrated that GBS patients have autoimmunologic abnormalities.Autoantibodies is as the most important pathogenic mechanism in GBS.We also found that the MBPAb both in serum and in CSF showed correlation between two samples.We consider that the MBPAb in CSF come from the serum.We think of it is useful for the GBS patients with plasma exchange therapy,be cause it can be eliminated those serum antibodies and antibodylike factors.

关 键 词：神经根炎 抗髓磷脂碱 蛋白 抗体 

分 类 号：R745.430.3[医药卫生—神经病学与精神病学]