山莨菪碱在缺血性脑卒中急性期应用的实验性研究  

Experimental study of 654-2 at acut period on ischemic stroke

作　　者：李秀珍[1] 陈沛源[1] 于治家[1] 李元瑛[2] 李丽君[2] 陈融[2] 

机构地区：[1]空军济南医院神经科,250031 [2]山东医科大学病理教研室

出　　处：《中风与神经疾病杂志》1994年第4期204-207,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：实验用家兔结扎双侧颈总及一侧椎动脉,造成严重的不完全脑缺血模型。分别于缺血后半小时、2小时注入654—2。结果:654—2可使缺血后脑血流量下降率明显低于对照组和生理盐水组(P<0.01)。血浆中TXB_2明显低于盐水组和对照组(P<0.01)。大脑皮层水、钠、钾含量和超微结构未见明显改变。此模型可用于研究脑缺血发病机制及实验治疗。本实验表明654—2可应于缺血性卒中急性期的治疗。Bilateral common carotid arteries and unilateral vertebroartery were ligated off in rabbits, which caused uncomplete ischaemic cerebral models After ischaemic occurrence .654 - 2 was respectively injected at half an hour and 2 hours. The regutls showed 654-2 can increase cerebral blood flow which have been decreased and TXB2 levels in plasma in 654- 2 group were markedly lower than in controled group (p<0. 01). Electron - microscope showed that H2O. K+ ,Na+ levels and ultrastructure were not obviously different in the cerebral cortices.

关 键 词：654-2 山莨菪碱 中风 

分 类 号：R743.305[医药卫生—神经病学与精神病学]