Maspin BCSG1及c-erbB-2表达与乳腺癌预后的关系  

The Relationship between the Maspin, BCSG1 and c-erbB-2 Expression and the Prognosis of Breast Cancer

作　　者：刘巍[1] 张祥宏[1] 张志刚[1] 王小玲[2] 王俊灵[1] 严霞[1] 

机构地区：[1]河北医科大学基础研究所实验病理室 [2]河北医科大学第四医院病理科

出　　处：《中国肿瘤临床》2005年第8期431-434,共4页Chinese Journal of Clinical Oncology

基　　金：河北省卫生厅科研基金资助(编号:02276103D-12)

摘　　要：目的:探讨Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达及其与预后的关系。方法:选取临床病理资料完整并随访5年以上的137例乳腺癌病例,采用SP免疫组织化学技术检测乳腺癌组织中的Maspin、BCSG1、c-erbB-2蛋白的表达情况,结合临床及病理形态学资料用COX模型分析Maspin、BCSG1、c-erbB-2表达对预后的影响。结果:Maspin、BCSG1、c-erbB-2蛋白在乳腺癌组织中的阳性表达率分别为48.9%,67.2%,27.7%三者与生存时间显著相关(P<0.01)。结论:Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达与患者的生存期密切相关,可作为预测乳腺癌预后的参考指标。Objective: To assess the relationship between the Maspin, BCSG1 and c-erbB-2 expression and the prognosis in breast cancer. Methods: The expression of ER, PR, Maspin, BCSG1, c-erbB-2 were determined with the SP immunohisto-chemical method in 137 cases with invasive breast cancer followed up over 5 years. Cox model was used to analyze the effect of Maspin, BCSG1 and c-erbB-2 expression and the clinopathological manifestations and prognosis in breast cancer. Results: The expression rate of Maspin, BCSG1 and c-erbB-2 was 48.9%, 67.2% and 27.7%, respectively, which were in relation with the survivals (P<0.01). Conclusion: The expression of BCSG1, c-erbB-2 and Maspin is closely related to the survival rate and can be used as the predictor of prognosis.

关 键 词：乳腺癌 MASPIN BCSGl c—erbB-2免疫组化预后 

分 类 号：R737.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]