2型糖尿病及合并冠心病糖尿病患者脂联素水平观察  

Observation of Plasma Concentrations of Adiponectin in Type 2 Diabetes and Diabetes with Coronary Heart Disease

作　　者：张洁红[1] 周其锋[2] 曾龙驿[3] 

机构地区：[1]广州医学院第一附属医院内分泌科,广东广州510120 [2]中山大学医学院免疫学教研室,广东广州510089 [3]中山大学附属第三医院内分泌科,广东广州510630

出　　处：《中国误诊学杂志》2005年第4期604-606,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:观察脂联素(adiponectin)在2型糖尿病(DM)及DM合并冠心病时的浓度变化,并探讨影响2型糖尿病患者血浆脂联素水平的因素。方法:用EL ISA方法在2型糖尿病组(无或合并冠心病)、非糖尿病正常对照组测定血浆脂联素水平。结果:无冠心病的糖尿病组血浆脂联素水平较非糖尿病正常对照组明显降低,合并冠心病的糖尿病组更低。结论:2型糖尿病中血浆脂联素水平的明显下降可作为冠心病的危险标志。Objective:To investigate the plasma adiponectin concentrations in type 2 diabetic patients and to study the relationship between adiponectin and type 2 diabetic patients with coronary artery disease (CAD).Methods:Plasma adiponectin concentrations were assayed by ELISA,which were determined in type 2 diabetic subjects with and without CAD,and nondiabetic.Results:The plasma adiponectin concentrations were significantly lower in diabetic without CAD than those in nondiabetic subjects.The plasma adiponectin concentrations were significantly lower in diabetic with CAD than those in diabetic without CAD subjects.Conclusion:These results suggested that the decreased plasma adiponectin concentrations in diabetes should be an risky factor of coronary heart disease.

关 键 词：胞间信号肽类和蛋白质类/血液 糖尿病 Ⅱ型/血液 糖尿病血管病变/血液 冠状动脉疾病/血液 

分 类 号：R587.23[医药卫生—内分泌]