体部伽玛刀治疗早期非小细胞肺癌初步临床研究  

Clinical study in treatment of early non-small cell lung cancer with whole-body gamma-knife

作　　者：单国用[1] 陈永顺[1] 宋淑兰[1] 

机构地区：[1]河南省郑州市第五人民医院,450003

出　　处：《临床医学》2005年第4期6-7,共2页Clinical Medicine

摘　　要：目的　研究体部伽玛刀治疗早期非小细胞肺癌的临床疗效。方法　对18 例I^II期非小细胞肺癌病例采用体部伽玛刀立体定向放射治疗,负压袋体模固定体位,螺旋CT增强扫描定位和三维适形治疗计划。处方剂量5Gy/次,5次/周,共10次,以50%等剂量曲线作为参考线。结果　原发灶完全缓解(CR) 12 例(66.7%),部分缓解(PR)6例(33.3%),无变化(NR)0例,总有效率(CR+PR)100%。18 例治疗按计划完成,放射性肺炎多数较轻,I级占27.8%(5/18),II级占5.6%(1/18)。1、2年肿瘤局部控制率分别为94.4%、77.8%。结论　体部伽玛刀治疗早期非小细胞肺癌近期疗效好,放射反应轻微,分次立体定向适形放疗是较为理想的放疗模式,可提高肿瘤的局部控制率。Objective In order to evaluate the effects and adverse reactions for Non-small Cell Lung Cancer(NSCLC)patients treated with the Gamma-ray Whole-body Stereotactic Radiotherapy System(γ-knife).Methods 18 patients with stage I^II NSCLC were treated with γ-knife.3-D treatment plan has been developed at a total dose of 50Gy, fractional periphery dose 5Gy per day(50% isodose line),5 times per week.Results All patients were analyzed to evaluate the clinical effects and complications.The complete remission rate (CR) in the primary tumor was 66.7%,and the partial remission rate(PR)33.3%(short term efficiency rate CR+PR=100%) after 2~3 months.Acute radiation-induced pneumonitis was observed in 6 of patients, among them Grade I 22.2%,Grade II 5.6%(RTOG).The 1-,2-year local control rates were 94.4%,77.8%.Conclusion This new technology,which is noninvasive、painless、rapid and not requiring hospitalization,does not impair the life quality of patient when used properly.Treatment has obtained a high response rate with minimal side effects.Remote results await further research.

关 键 词：体部伽玛刀 非小细胞肺癌 放射治疗 放射源体 

分 类 号：R734.2[医药卫生—肿瘤] R730.55[医药卫生—临床医学]