超氧化物歧化酶对大鼠乙酸性结肠炎粘膜的保护作用  

Mucosal protective effect of superoxide dismutase on acetic-acid-induced colitisin rat

作　　者：邓长生[1] 夏冰[1] 陈德基[1] 周燕[1] 龚玲玲[1] 高志清[1] 

机构地区：[1]湖北医科大学附属第二医院消化内科

出　　处：《中国病理生理杂志》1994年第1期23-26,共4页Chinese Journal of Pathophysiology

摘　　要：本文观察了超氧化物歧化酶（ＳＯＤ）对大鼠乙酸性结肠炎的粘膜保护作用。与生理盐水组对照，预防性静脉给予１万ＵＳＯＤ能显著降低粘膜损伤指数以及肠粘连和狭窄的发生率。但是，腹腔注射与灌肠相同剂量的ＳＯＤ与各自生理盐水对照组比较，并无显著差别。ＳＯＤ的粘膜保护作用呈剂量效应。测定结肠粘膜ＳＯＤ、谷胱甘肽过氧化物酶、髓过氧化物酶活性以及过氧化脂质含量，提示ＳＯＤ的保护作用机理是减少炎症过程中的氧自由基。The colonic mucosal protective effect of superoxide dismutase ( SOD )onacetic acid-induced colitis in rats was observed.The mucosal damage index and occurrenceof intestinal adhesion and stricture in the group pretreated intravenously with 10,000U ofSOD were more significantlydecreased than those in the group with normal saline,butno significant differences were existed between the damage index in peritoneal or enemagroup pretreated with the same dose of SOD and in normal saline group.SOD showedthe dose dependent in the mucosal protection.Assay of SOD,glutathione peroxidase(GSH-px )and myeloperoxidase ( MPO)activity and product of lipid peroxidation(LPO )incolonic mucosa indicates thatthe pathogenesis of mucosal protective effect of SOD is toreduce oxygen free radicalsin inflammation processes.

关 键 词：结肠炎 大鼠 超氧物歧化酶 

分 类 号：R574.620.2[医药卫生—消化系统]