ATP－MgCl_2对小肠缺血和再灌注损伤的保护作用及机理研究  

The protective effect of ATP-MgCl_2 in small intestinal ischemia and reperfusion and its mechanism

作　　者：廖贤平[1] 余亚雄[1] 施诚仁[1] 张忠德[1] 李敏[1] 

机构地区：[1]上海第二医科大学新华医院

出　　处：《中国病理生理杂志》1994年第3期283-287,共5页Chinese Journal of Pathophysiology

摘　　要：采用新西兰白兔制成的模型研究ＡＴＰ－ＭｇＣｌ＿２对肠缺血－再灌注损伤的保护作用及机制。结果表明静脉输注ＡＴＰ－ＭｇＣｌ＿２可显著降低血清脂质过氧化物，减轻缺血和再灌注所导致的损伤，避免再灌注阶段线粒体的进一步损害。提示ＡＴＰ－ＭｇＣｌ＿２抑制氧自由基生成和增强细胞抗氧自由基能力的作用是它对细胞缺血缺氧保护作用的可能机制之一。To study the protective effect of ATP-MgCl_2 following intestinal ischemiaand reperfusion and its mechanism, a rabbit model was established.The results showed thatinfusion of ATP-MgCl_2 did lower serum lipid peroxide level significantly, reduced intes-tinal ischemic and reperfusion injury, and avoid further damage of mitochondria duringreperfusion phase. These findings suggested that inhibition of oxygen free radical productionand strengthening intracellular antioxidant defense system may be one of the potentialmechanisms of the benifitial effects of ATP-MgCl_2 in cellular ischemia and anoxia.

关 键 词：腺苷三磷酸 再灌注损伤 小肠 缺血 

分 类 号：R363.27[医药卫生—病理学]